RAB3IP Antibody

Datasheet

Code	CSB-PA853488LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA853488LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA853488LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB3IP Polyclonal antibody

Uniprot No.

Q96QF0

Target Names

RAB3IP

Alternative Names

Gtpat12 antibody; Rab-3A-interacting protein antibody; RAB3A interacting protein antibody; RAB3A interacting protein (rabin3) antibody; RAB3A interacting protein antibody; RAB3A-interacting protein antibody; RAB3I_HUMAN antibody; Rab3ip antibody; Rabin 3 antibody; Rabin-3 antibody; RABIN3 antibody; RABIN3; rat; homolog of antibody; Rabin8 antibody; SSX2 interacting protein antibody; SSX2 interacting protein antibody; SSX2-interacting protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Rab-3A-interacting protein (1-132AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RAB3IP Antibody (Product code: CSB-PA853488LA01HU) is Non-conjugated. For RAB3IP Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA853488LB01HU	RAB3IP Antibody, HRP conjugated	ELISA
FITC	CSB-PA853488LC01HU	RAB3IP Antibody, FITC conjugated
Biotin	CSB-PA853488LD01HU	RAB3IP Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

Gene References into Functions

Authors show that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex. PMID: 26258637
the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined. PMID: 25787272
Rab11-FIP3 coordinates the interactions of ASAP1 and Rab11a with Rabin8. PMID: 25673879
Rabin8 was identified as a direct phospho-substrate of ERK1/2 in response to EGF signaling. PMID: 25535387
RABIN3 interacts with the cancer-related protein SSX2 and a novel nuclear protein, SSX2IP. PMID: 12007189

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Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

SEC2 family

Tissue Specificity

Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.

Database Links

HGNC: 16508

OMIM: 608686

KEGG: hsa:117177

STRING: 9606.ENSP00000447300

UniGene: Hs.258209

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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