RAB3IP Antibody

Datasheet

Code	CSB-PA006887
Size	US$100
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Image	Western Blot analysis of K562 cells using RAB3IP Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q96QF0

Target Names

RAB3IP

Alternative Names

Gtpat12 antibody; Rab-3A-interacting protein antibody; RAB3A interacting protein antibody; RAB3A interacting protein (rabin3) antibody; RAB3A interacting protein antibody; RAB3A-interacting protein antibody; RAB3I_HUMAN antibody; Rab3ip antibody; Rabin 3 antibody; Rabin-3 antibody; RABIN3 antibody; RABIN3; rat; homolog of antibody; Rabin8 antibody; SSX2 interacting protein antibody; SSX2 interacting protein antibody; SSX2-interacting protein antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human RAB3IP.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.

Gene References into Functions

Authors show that Rab11-GMPPNP-FIP3-Rabin8 is more stable than Rab11-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex. PMID: 26258637
the role of Rabin8 (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined. PMID: 25787272
Rab11-FIP3 coordinates the interactions of ASAP1 and Rab11a with Rabin8. PMID: 25673879
Rabin8 was identified as a direct phospho-substrate of ERK1/2 in response to EGF signaling. PMID: 25535387
RABIN3 interacts with the cancer-related protein SSX2 and a novel nuclear protein, SSX2IP. PMID: 12007189

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Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

SEC2 family

Tissue Specificity

Expressed in brain, kidney, heart, pancreas and placenta. Not detected in skeletal muscle or liver.

Database Links

HGNC: 16508

OMIM: 608686

KEGG: hsa:117177

STRING: 9606.ENSP00000447300

UniGene: Hs.258209

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Service

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Protein Service

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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