RAB7B Antibody

Datasheet

Code	CSB-PA019220LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA019220LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RAB7B Polyclonal antibody

Uniprot No.

Q96AH8

Target Names

RAB7B

Alternative Names

MGC16212 antibody; MGC9726 antibody; RAB7 antibody; rab7B antibody; RAB7B; member RAS oncogene family antibody; RAB7B_HUMAN antibody; Ras related protein Rab 7b antibody; Ras-related protein Rab-7B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ras-related protein Rab-7b protein (100-199AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RAB7B Antibody (Product code: CSB-PA019220LA01HU) is Non-conjugated. For RAB7B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA019220LB01HU	RAB7B Antibody, HRP conjugated	ELISA
FITC	CSB-PA019220LC01HU	RAB7B Antibody, FITC conjugated
Biotin	CSB-PA019220LD01HU	RAB7B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IF

Recommended Dilution

Application	Recommended Dilution
IF	1:50-1:200

Protocols

ELISA Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Gene References into Functions

study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B PMID: 28835545
Authors determined the effects of T. suis soluble products (SPs) on Toll-like receptor-4 (TLR4)- In addition, T. suis SPs induce Rab7b, a negative regulator of TLR4 signalling PMID: 25996526
Rab9a and Rab7b are mediators of the transit of the L2 capsid protien and the pseudogenome of human papillomavirus 16 from the late endosome to the golgi complex. PMID: 23345514
Rab7b is required for sortilin transport from endosomes to the TGN. PMID: 22708738
Rab7b may play important roles in megakaryopoiesis by activating NF-kappaB and promoting IL-6 production. PMID: 20953574
Rab7b is required for normal lysosome function, and, in particular, it is an essential factor for retrograde transport from endosomes to the trans-Golgi network. PMID: 20375062

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Subcellular Location

Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side.

Protein Families

Small GTPase superfamily, Rab family

Tissue Specificity

Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.

Database Links

HGNC: 30513

KEGG: hsa:338382

UniGene: Hs.534612

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Autophagy Mitophagy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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