Ras-related protein Rab-7bis a protein in humans that is encoded by RAB7B gene. Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
The following RAB7B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RAB7B Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019220GA01HU | RAB7B Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA019220LA01HU | RAB7B Antibody |
Human | ELISA, IF |
CSB-PA019220LB01HU | RAB7B Antibody, HRP conjugated |
Human | ELISA |
CSB-PA019220LC01HU | RAB7B Antibody, FITC conjugated |
Human |
RAB7B Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP600945BO CSB-EP600945BO CSB-BP600945BO CSB-MP600945BO CSB-EP600945BO-B |
Recombinant Bovine Ras-related protein Rab-7b (RAB7B) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAB7B Proteins for Dictyostelium discoideum (Slime mold)
Code | Product Name | Source |
---|---|---|
CSB-YP700778DKK CSB-EP700778DKK CSB-BP700778DKK CSB-MP700778DKK CSB-EP700778DKK-B |
Recombinant Dictyostelium discoideum Ras-related protein Rab-7B (rab7B) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAB7B Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP845015MO CSB-EP845015MO CSB-BP845015MO CSB-MP845015MO CSB-EP845015MO-B |
Recombinant Mouse Ras-related protein Rab-7b (Rab7b) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAB7B Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP853383HU CSB-EP853383HU CSB-BP853383HU CSB-MP853383HU CSB-EP853383HU-B |
Recombinant Human Ras-related protein Rab-7b (RAB7B) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |