RAD54L Antibody

Code CSB-PA070022
Size US$167
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Product Details

Uniprot No. Q92698
Target Names RAD54L
Alternative Names DNA repair and recombination protein RAD54 like antibody; DNA repair and recombination protein RAD54-like antibody; hHR 54 antibody; hHR54 antibody; HR 54 antibody; HR54 antibody; hRAD 54 antibody; hRAD54 antibody; RAD 54A antibody; RAD 54L antibody; RAD54 (S. cerevisiae) like antibody; RAD54 homolog antibody; RAD54 like (S. cerevisiae) antibody; RAD54 like antibody; RAD54 like protein antibody; RAD54_HUMAN antibody; RAD54A antibody; RAD54L antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the Internal region of Human Rad54.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
Gene References into Functions
  1. Data show that the RAD54 N-terminal domain (NTD) is responsible for initiation of branch migration (BM) through two coupled, but distinct steps; specific binding to Holliday junctions and RAD54 oligomerization. PMID: 29295984
  2. Nap1 binds to RAD54. PMID: 24798879
  3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
  4. support a model in which RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in tumor cells PMID: 25765654
  5. The RAD54L polymorphism (2290C/T) can be used as a genetic marker inside the consensus deletion region at 1p32 in human meningiomas. PMID: 12614485
  6. Shortened telomeres in murine scid cells expressing mutant RAD54L coincide wirth reduction in recombination at telomeres. PMID: 15975611
  7. hRad54, a Swi2/Snf2 protein, binds HJ-like structures with high specificity and promotes their bidirectional branch migration in an ATPase-dependent manner PMID: 16862129
  8. Some immortal cells use the alternative lengthening of telomeres (ALT) pathway to maintain their telomeres instead of telomerase. This is the first genetic evidence that Rad54 is dispensable for the ALT pathway. PMID: 17054727
  9. RAD54 is recruited by RAD51-ssDNA filament to the chromatin of the intact chromosome and it remodels that chromatin to facilitate accessibility for strand exchange PMID: 17417655
  10. analysis of human rad54 protein interactions with branched DNA molecules PMID: 17545145
  11. Rad54 protein causes dissociation of joint molecules by ATP-dependent branch-migration and therefore plays an important role in double strand DNA break repair. PMID: 17660833
  12. germline mutations in RAD51, RAD51AP1, RAD51L1, RAD51L3, RAD52 and RAD54L are unlikely to be causal of an inherited predisposition to CLL. PMID: 18203022
  13. Rad51 protein stimulates the branch migration activity of Rad54 protein.( PMID: 18617519

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Subcellular Location Nucleus
Protein Families SNF2/RAD54 helicase family
Database Links

HGNC: 9826

OMIM: 603615

KEGG: hsa:8438

STRING: 9606.ENSP00000361043

UniGene: Hs.642042

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