RASGRP3 Antibody

Code CSB-PA808539ESR2HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RASGRP3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Calcium and DAG-regulated guanine nucleotide exchange factor III antibody; Grp3 antibody; GRP3_HUMAN antibody; Guanine nucleotide exchange factor for Rap1 antibody; Kiaa0846 antibody; RAS guanyl releasing protein 3 (calcium and DAG regulated) antibody; RAS guanyl releasing protein 3 calcium and DAG regualated guanine nucleotide exchange factor iii antibody; Ras guanyl-releasing protein 3 antibody; RASGRP3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ras guanyl-releasing protein 3 protein (541-690AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
Gene References into Functions
  1. In conclusion, these findings provide a new insight into the upregulation of RasGRP3 involved in Notch pathway activation in the development of esophageal squamous cell carcinoma , especially under nutrient deprivation. PMID: 29048643
  2. these data show that RasGRP3 exerts its oncogenic effect in papillary thyroid cancer through Akt-mediated MDM2 activation. PMID: 28864115
  3. RasGRP3 mediates ERK MAPK pathway activation in GNAQ mutant uveal melanoma. PMID: 28486107
  4. Knockdown of RasGRP3 inhibited proliferation in prostate neoplasms. PMID: 24418912
  5. Ras activator RasGRP3 may have a role in the pathological behavior of breast cancer cells and may constitute a therapeutic target for human breast cancer. PMID: 24779681
  6. The identification of the role of RasGRP3 in melanoma highlights its importance, as a Ras activator, in the phosphoinositide signaling pathway in human melanoma. PMID: 21602881
  7. Significant associations were found for the single nucleotide polymorphism rs13385731 of RasGRP3 with malar rash, discoid rash, and antinuclear antibody in patients with systemic lupus erythematosus PMID: 20516000
  8. RasGRP3 contributes to the malignant phenotype of prostate cancer cells and may constitute a novel therapeutic target for human prostate cancer. PMID: 20876802
  9. A vascular gene trap screen defines RASGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters. PMID: 15572660
  10. studies support the hypothesis that RasGRP phosphorylation by PKC is a mechanism that integrates DAG signaling systems in T and B cells PMID: 15657177
  11. dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellular localization of the exchange factor PMID: 17012239

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Protein Families
RASGRP family
Database Links

HGNC: 14545

OMIM: 609531

KEGG: hsa:25780

STRING: 9606.ENSP00000384192

UniGene: Hs.143674

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