RBBP6 Antibody

1. RBBP6 might potentiate cervical carcinoma cell viability. PMID: 29501043
2. Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP6 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
3. RBBP6 overexpression could resist colorectal cancer cells against radiation. PMID: 29369481
4. These results suggest that the RBBP6-3 isoform may be involved in promoting apoptosis in cancerous cells. PMID: 26905308
5. RBBP6 is a candidate gene for myeloproliferative neoplasms (MPNs) susceptibility in a subset of pedigrees with familial MPN. PMID: 26574608
6. High expression levels of RBBP6 and high apoptosis levels were found in HIV-associated nephropathy (HIVAN) cases. This direct association between RBBP6 expression and apoptosis levels suggests that RBBP6 play a role in HIVAN pathogenesis. PMID: 25910411
7. gene silencing sensitises breast cancer cells to staurosporine and camptothecin-induced cell death PMID: 24703106
8. RBBP6 prevents DNA damage by destabilizing the transcriptional repressor ZBTB38. PMID: 24726359
9. RBBP6 gene variants are associated with glioma and contribute to glioma susceptibility PMID: 25127414
10. implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs. PMID: 25319826
11. these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be deregulated in carcinogenesis PMID: 22139301
12. AGO2, PACT and TRBP are required for the efficient functioning of Dicer in cells PMID: 22163034
13. Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control. PMID: 22130672
14. RBBP6 may be involved in the degradation of p53, thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer. PMID: 21676486
15. P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression PMID: 15617101
16. RBBP6 has a role in mRNA processing and ubiquitin-like pathways PMID: 16396680
17. The authors showed that RBBP6 and its isolated RING finger domain were able to ubiquitinate YB-1, resulting in its degradation in the proteosome. As a result, RBBP6 was able to suppress the levels of YB-1 in vivo and reduce its transactivational ability. PMID: 18851979

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HGNC: 9889

OMIM: 600938

KEGG: hsa:5930

STRING: 9606.ENSP00000317872

UniGene: Hs.188553