Name: RBBP6 Antibody
Brand: CUSABIO
SKU: CSB-PA768776LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RBBP6 Polyclonal antibody

Uniprot No.

Q7Z6E9

Target Names

RBBP6

Alternative Names

DKFZp686P0638 antibody; DKFZp761B2423 antibody; E3 ubiquitin-protein ligase RBBP6 antibody; MY038 antibody; P2P R antibody; P2PR antibody; p53 associated cellular protein of testis antibody; p53-associated cellular protein of testis antibody; p53-associated cellular protein, testis-derived antibody; PACT antibody; Proliferation potential related protein antibody; Proliferation potential-related protein antibody; Protein P2P R antibody; Protein P2P-R antibody; Protein P2PR antibody; Protein RBQ 1 antibody; Protein RBQ1 antibody; RB binding protein 6, ubiquitin ligase antibody; RB binding Q protein 1 antibody; RBBP 6 antibody; Rbbp6 antibody; RBBP6_HUMAN antibody; RBQ 1 antibody; RBQ-1 antibody; RBQ1 antibody; Retinoblastoma binding protein 6 isoform 3 antibody; Retinoblastoma binding Q protein 1 antibody; Retinoblastoma-binding protein 6 antibody; Retinoblastoma-binding Q protein 1 antibody; SNAMA antibody; SNAMA, Drosophila, homolog of antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human E3 ubiquitin-protein ligase RBBP6 protein (51-97AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RBBP6 Antibody (Product code: CSB-PA768776LA01HU) is Non-conjugated. For RBBP6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA768776LB01HU	RBBP6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA768776LC01HU	RBBP6 Antibody, FITC conjugated
Biotin	CSB-PA768776LD01HU	RBBP6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO's product CSB-PA768776LA01HU is a polyclonal antibody against the RBBP6 protein. It is produced in the rabbit immunized with a partial recombinant protein mapping within 51-97 amino acids of the human RBBP6. Its purity reaches up to 95% using protein G purified. This RBBP6 antibody has been validated for use in ELISA, WB, IHC, and IF applications. And it reacts with human and mouse RBBP6 proteins.

RBBP6 protein, also known as p53-dependent damage-inducible nuclear protein 1 (p53DINP1), is a multifunctional protein that plays important roles in various cellular processes, including DNA damage response, transcriptional regulation, and protein quality control. Mutations or dysregulation of RBBP6 can lead to various human diseases, including cancer, neurodegenerative disorders, and metabolic disorders.

Target Background

Function

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication.; (Microbial infection) restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription.

Gene References into Functions

RBBP6 might potentiate cervical carcinoma cell viability. PMID: 29501043
Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP6 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
RBBP6 overexpression could resist colorectal cancer cells against radiation. PMID: 29369481
These results suggest that the RBBP6-3 isoform may be involved in promoting apoptosis in cancerous cells. PMID: 26905308
RBBP6 is a candidate gene for myeloproliferative neoplasms (MPNs) susceptibility in a subset of pedigrees with familial MPN. PMID: 26574608
High expression levels of RBBP6 and high apoptosis levels were found in HIV-associated nephropathy (HIVAN) cases. This direct association between RBBP6 expression and apoptosis levels suggests that RBBP6 play a role in HIVAN pathogenesis. PMID: 25910411
gene silencing sensitises breast cancer cells to staurosporine and camptothecin-induced cell death PMID: 24703106
RBBP6 prevents DNA damage by destabilizing the transcriptional repressor ZBTB38. PMID: 24726359
RBBP6 gene variants are associated with glioma and contribute to glioma susceptibility PMID: 25127414
implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs. PMID: 25319826
these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be deregulated in carcinogenesis PMID: 22139301
AGO2, PACT and TRBP are required for the efficient functioning of Dicer in cells PMID: 22163034
Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control. PMID: 22130672
RBBP6 may be involved in the degradation of p53, thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer. PMID: 21676486
P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression PMID: 15617101
RBBP6 has a role in mRNA processing and ubiquitin-like pathways PMID: 16396680
The authors showed that RBBP6 and its isolated RING finger domain were able to ubiquitinate YB-1, resulting in its degradation in the proteosome. As a result, RBBP6 was able to suppress the levels of YB-1 in vivo and reduce its transactivational ability. PMID: 18851979

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Subcellular Location

Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.

Tissue Specificity

Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.

Database Links

HGNC: 9889

OMIM: 600938

KEGG: hsa:5930

STRING: 9606.ENSP00000317872

UniGene: Hs.188553

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Code	CSB-PA768776LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse brain tissue All lanes: RBBP6 antibody at 2.7μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 202, 198, 14, 107 kDa Observed band size: 202 kDa Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA768776LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA768776LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA768776LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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RBBP6 Antibody

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Target Background