RBP2 Antibody

Code CSB-PA005623
Size US$100
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  • Western Blot analysis of K562 cells using CRBP II Polyclonal Antibody.
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Product Details

Uniprot No.
Target Names
RBP2
Alternative Names
Cellular retinol binding protein II antibody; Cellular retinol-binding protein II antibody; CRABP II antibody; Crbp 2 antibody; CRBP II antibody; CRBP-II antibody; CRBP2 antibody; CrbpII antibody; MGC159254 antibody; MGC159256 antibody; Rbp 2 antibody; Rbp2 antibody; RBPC2 antibody; RET2_HUMAN antibody; Retinol binding protein 2 antibody; Retinol binding protein 2 cellular antibody; Retinol-binding protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human CRBP II.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Intracellular transport of retinol.
Gene References into Functions
  1. study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses PMID: 28970247
  2. Domain-swapped dimers of RBP2 provides evidence for ordered folding intermediates. PMID: 27524203
  3. The structure of retinal-bound human CRBPII and the structure of retinol-bound CRBPII with retinol fully occupying the binding pocket are reported. PMID: 25478840
  4. With only nine point mutations, the hCRBPII mutants induced a systematic shift in the absorption profile of all-trans-retinal of more than 200 nanometers across the visible spectrum. PMID: 23224553
  5. retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation. PMID: 12016134
  6. We report here the X-ray structures of human apo and holo CRBP II solved at 1.2 A resolution and compare the two structures between them and with the structures of zebrafish and rat CRBP II. PMID: 18076076
  7. HNF-4alpha is an important transcriptional factor that regulates human CRBPII gene expression; possibility for a novel function of HNF-4alpha in the regulation of human intestinal vitamin A absorption and metabolism PMID: 19147806

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Subcellular Location
Cytoplasm.
Protein Families
Calycin superfamily, Fatty-acid binding protein (FABP) family
Tissue Specificity
Higher expression in adult small intestine and to a much lesser extent in fetal kidney.
Database Links

HGNC: 9920

OMIM: 180280

KEGG: hsa:5948

STRING: 9606.ENSP00000232217

UniGene: Hs.655516

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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