RCE1 Antibody, FITC conjugated

Datasheet

Code	CSB-PA896686LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RCE1 Polyclonal antibody

Uniprot No.

Q9Y256

Target Names

RCE1

Alternative Names

RCE1; FACE2; RCE1A; RCE1B; CAAX prenyl protease 2; Farnesylated proteins-converting enzyme 2; FACE-2; Prenyl protein-specific endoprotease 2; RCE1 homolog; hRCE1

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CAAX prenyl protease 2 protein (133-185AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.

Gene References into Functions

High expression of Rce1 is associated with renal cell carcinoma. PMID: 28159979
RCE1 acts as a tumor suppressor in CRC, as its reduced expression may increase CRC cell invasion and independently predict an unsatisfactory prognosis in CRC patients. PMID: 28615075
Suggests that expression of Rce1 can serve as an independent biomarker for the prognosis of prostate carcinoma patients. PMID: 26546252
A novel RCE1 isoform is required for H-Ras plasma membrane localization regulated by ubiquitin specific peptidase (USP)17. PMID: 24134311
We found that an 8-aa K-Ras-derived "CAA" peptide, KSKTKC(farnesyl)VI, was a better substrate for hRCE1 than a KSKTKC(f)VIM "CAAX" peptide, hRCE1 has important interaction with the P2' and P3' substrate positions in addition to the farnesylated cysteine PMID: 12818187
CAAX endoprotease Rce1 is required for lamin B1 endoproteolysis PMID: 14504265
the ras converting enzyme requires its glutamate and histidine residues PMID: 16361710

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

Peptidase U48 family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 13721

OMIM: 605385

KEGG: hsa:9986

STRING: 9606.ENSP00000309163

UniGene: Hs.654972

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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