REC8 Antibody

Datasheet

Code	CSB-PA019535ESR1HU
Size	US$166
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Image	Western blot All lanes: REC8 antibody at 1.67µg/ml Lane 1: Jurkat whole cell lysate Lane 2: HT29 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 63, 61 kDa Observed band size: 63 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019535ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA019535ESR1HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) REC8 Polyclonal antibody

Uniprot No.

O95072

Target Names

REC8

Alternative Names

Cohesin Rec8p antibody; Human homolog of rad21 S. pombe antibody; Meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family antibody; Meiotic recombination protein REC8 homolog antibody; Meiotic recombination protein REC8-like 1 antibody; rec8 antibody; REC8 homolog (yeast) antibody; REC8 like 1 antibody; REC8_HUMAN antibody; Rec8p antibody; Recombination and sister chromatid cohesion protein homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Meiotic recombination protein REC8 homolog protein (1-270AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

Gene References into Functions

we determined that REC8 interacted with EGR1, and inhibited EMT in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 and EGR1 to potentially find novel targets in the treatment for gastric cancer. PMID: 29393474
Study confirmed that REC8 was downregulated in gastric neoplasm, especially in the EBV-associated subtype, via promoter methylation. PMID: 27212034
REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K pathway. Aberrant inactivation of REC8 through hypermethylation by the PI3K pathway may represent an important mechanism mediating the oncogenic functions of the PI3K pathway PMID: 26472282
Indicate that polymorphisms of the Rec 8 gene are not a common cause of severe male factor infertility. PMID: 18570052
Data show that REC8 is constitutively expressed in tumour cells, along with SGOL1 and SGOL2, and that REC8 becomes modified after irradiation. PMID: 19463812
The mouse ortholog of REC8L1 is required for proper synapsis of homologous chromosomes during meiosis PMID: 15935783

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Subcellular Location

Nucleus. Chromosome. Chromosome, centromere.

Protein Families

Rad21 family

Tissue Specificity

Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level).

Database Links

HGNC: 16879

OMIM: 608193

KEGG: hsa:9985

STRING: 9606.ENSP00000308699

UniGene: Hs.419259

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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