REC8 Antibody

1. we determined that REC8 interacted with EGR1, and inhibited EMT in gastric cancer cells. We thus propose further studies of the pathways associated with REC8 and EGR1 to potentially find novel targets in the treatment for gastric cancer. PMID: 29393474
2. Study confirmed that REC8 was downregulated in gastric neoplasm, especially in the EBV-associated subtype, via promoter methylation. PMID: 27212034
3. REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K pathway. Aberrant inactivation of REC8 through hypermethylation by the PI3K pathway may represent an important mechanism mediating the oncogenic functions of the PI3K pathway PMID: 26472282
4. Indicate that polymorphisms of the Rec 8 gene are not a common cause of severe male factor infertility. PMID: 18570052
5. Data show that REC8 is constitutively expressed in tumour cells, along with SGOL1 and SGOL2, and that REC8 becomes modified after irradiation. PMID: 19463812
6. The mouse ortholog of REC8L1 is required for proper synapsis of homologous chromosomes during meiosis PMID: 15935783

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HGNC: 16879

OMIM: 608193

KEGG: hsa:9985

STRING: 9606.ENSP00000308699

UniGene: Hs.419259