RHBDL2 Antibody, FITC conjugated

Code CSB-PA019672LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RHBDL2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
RHBDL2 antibody; Rhomboid-related protein 2 antibody; RRP2 antibody; EC antibody; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2 antibody; N-terminal fragment antibody; NTF); Rhomboid-related protein 2 antibody; C-terminal fragment antibody; CTF)] antibody
Raised in
Species Reactivity
Recombinant Human Rhomboid-related protein 2 protein (12-132AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.
Gene References into Functions
  1. Thrombomodulin and RHBDL2 are upregulated in human HaCaT cells stimulated by scratch wounds; furthermore, increased solulbe thrombomodulin was found in culture medium. PMID: 21833011
  2. RHBDL2 cleaves epidermal growth factor just outside its transmembrane domain, thereby facilitating its secretion and triggering activation of the epidermal growth factor receptor. PMID: 21494248
  3. Substrate specificity of RHBDL2 intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
  4. Here, the authors show that RHBDL2 is produced as a proenzyme and that the processing of RHBDL2 is required for its cellular protease activity. PMID: 19850051
  5. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. PMID: 15047175

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Subcellular Location
[Rhomboid-related protein 2, C-terminal fragment]: Cell membrane; Multi-pass membrane protein.
Protein Families
Peptidase S54 family
Database Links

HGNC: 16083

OMIM: 608962

KEGG: hsa:54933

STRING: 9606.ENSP00000289248

UniGene: Hs.524626

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