RNH1 Antibody

Datasheet

Code	CSB-PA904655
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA904655(RNH1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA904655(RNH1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal brain tissue, Human normal liver tissue, human normal kidney tissue, hepg2 cells, Primary antibody: CSB-PA904655(RNH1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P13489

Target Names

RNH1

Alternative Names

AW546468 antibody; C80305 antibody; MGC18200 antibody; MGC4569 antibody; MGC54054 antibody; OTTHUMP00000147628 antibody; OTTHUMP00000229864 antibody; OTTHUMP00000229865 antibody; OTTHUMP00000229866 antibody; OTTHUMP00000229870 antibody; OTTHUMP00000229871 antibody; OTTHUMP00000229872 antibody; Placental ribonuclease inhibitor antibody; Placental RNase inhibitor antibody; PRI antibody; RAI antibody; RI antibody; Ribonuclease inhibitor antibody; Ribonuclease/angiogenin inhibitor 1 antibody; Ribonuclease/angiogenin inhibitor antibody; RINI_HUMAN antibody; RNase inhibitor antibody; RNH 1 antibody; RNH antibody; RNH1 antibody; Rnh1 ribonuclease/angiogenin inhibitor 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human RNH1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene References into Functions

Results show that a low expression of RNH1 in metastasis of bladder cancer and suggest that it might regulate the function of ILK through mutual binding. PMID: 27576342
a novel mechanism of ANG in regulating PI3K/AKT/mTOR signaling pathway via RI, is reported. PMID: 25193113
RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. PMID: 24107847
angiogenin and ILK signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth PMID: 24769129
RI could play a novel role in inhibiting metastasis of bladder cancer through regulating EMT and ILK signaling pathways. PMID: 24768914
RNH1 as a regulator of HDACi resistance in gastric cancer PMID: 23584480
RI might play a novel role in the development of bladder cancer through regulating EMT and the ILK signaling pathway. PMID: 23703635
the anti-tumor effect of RNH1 is also involved in suppressing growth and metastasis PMID: 21125316
RNH1 (as a recombinant fusion protein) is localized to mitochondria, nuclei, and cytosol in HeLa and HCT cells; RNH1 appears to bind to various mitochondrial proteins. PMID: 21276451
Human ribonuclease inhibitor gene has antiangiogenic and antitumor effects when expressed in hematopoietic cells in mouse melanoma models. PMID: 15592448
The conformational and oxidative stabilities of both RIs increase upon complex formation with ribonucleases. Thus, RI has evolved to maintain its inhibition of invading ribonucleases, even when confronted with extreme environmental stress. PMID: 17956129
This the first measurement of the inhibition of the ribonucleolytic activity of onconase by ribonuclease inhibitor protein. PMID: 18930025

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Subcellular Location

Cytoplasm.

Database Links

HGNC: 10074

OMIM: 173320

KEGG: hsa:6050

STRING: 9606.ENSP00000346402

UniGene: Hs.530687

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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