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Lead Time
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Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells.
Gene References into Functions
genetic alterations in RPH3AL are associated with aggressive behavior of breast cancers and with short survival of patients. PMID: 26070152
Mutations of rabphillin-3A-like gene is associated with colorectal cancers PMID: 12375017
Noc2 may function as a Rab3B effector protein in epithelial cells. PMID: 15003533
Subcellular Location
Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.
Tissue Specificity
Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.