RPN1 Antibody

Code CSB-PA05124A0Rb
Size US$166
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  • Western blot
    All lanes: RPN1 antibody at 2µg/ml
    Lane 1: EC109 whole cell lysate
    Lane 2: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/15000 dilution
    Predicted band size: 50 kDa
    Observed band size: 50 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA05124A0Rb at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RPN1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
D6Wsu137e antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit precursor antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 antibody; EC 2.4.1.119 antibody; Oligosaccharyltransferase 1 homolog antibody; oligosaccharyltransferase complex subunit (non-catalytic) antibody; OST1 antibody; RBPH1 antibody; Ribophorin I antibody; Ribophorin-1 antibody; RPN-I antibody; Rpn1 antibody; RPN1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit protein (44-427AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RPN1 Antibody (Product code: CSB-PA05124A0Rb) is Non-conjugated. For RPN1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA05124B0Rb RPN1 Antibody, HRP conjugated ELISA
FITC CSB-PA05124C0Rb RPN1 Antibody, FITC conjugated
Biotin CSB-PA05124D0Rb RPN1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Gene References into Functions
  1. These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway. PMID: 25451265
  2. Data indicate that malectin functions by forming a complex with ribophorin I. PMID: 22988243
  3. ribophorin I can regulate the delivery of precursor proteins to the OST complex by capturing substrates and presenting them to the catalytic core. PMID: 18607003
Subcellular Location
Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Families
OST1 family
Tissue Specificity
Expressed in all tissues tested.
Database Links

HGNC: 10381

OMIM: 180470

KEGG: hsa:6184

STRING: 9606.ENSP00000296255

UniGene: Hs.518244

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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