RPN1 Antibody

Datasheet

Code	CSB-PA05124A0Rb
Size	US$166
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Image	Western blot All lanes: RPN1 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 50 kDa Observed band size: 50 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA05124A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) RPN1 Polyclonal antibody

Uniprot No.

P04843

Target Names

RPN1

Alternative Names

D6Wsu137e antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit precursor antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 antibody; EC 2.4.1.119 antibody; Oligosaccharyltransferase 1 homolog antibody; oligosaccharyltransferase complex subunit (non-catalytic) antibody; OST1 antibody; RBPH1 antibody; Ribophorin I antibody; Ribophorin-1 antibody; RPN-I antibody; Rpn1 antibody; RPN1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit protein (44-427AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The RPN1 Antibody (Product code: CSB-PA05124A0Rb) is Non-conjugated. For RPN1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA05124B0Rb	RPN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA05124C0Rb	RPN1 Antibody, FITC conjugated
Biotin	CSB-PA05124D0Rb	RPN1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

Gene References into Functions

These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway. PMID: 25451265
Data indicate that malectin functions by forming a complex with ribophorin I. PMID: 22988243
ribophorin I can regulate the delivery of precursor proteins to the OST complex by capturing substrates and presenting them to the catalytic core. PMID: 18607003

Subcellular Location

Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Families

OST1 family

Tissue Specificity

Expressed in all tissues tested.

Database Links

HGNC: 10381

OMIM: 180470

KEGG: hsa:6184

STRING: 9606.ENSP00000296255

UniGene: Hs.518244

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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