RPN1 Antibody

Datasheet

Code	CSB-PA233350
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA233350(RPN1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA233350(RPN1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, A549 cells, human liver cancer tissue, Primary antibody: CSB-PA233350(RPN1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

P04843

Target Names

RPN1

Alternative Names

D6Wsu137e antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit antibody; Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit precursor antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit antibody; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 antibody; EC 2.4.1.119 antibody; Oligosaccharyltransferase 1 homolog antibody; oligosaccharyltransferase complex subunit (non-catalytic) antibody; OST1 antibody; RBPH1 antibody; Ribophorin I antibody; Ribophorin-1 antibody; RPN-I antibody; Rpn1 antibody; RPN1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human RPN1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

Gene References into Functions

These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway. PMID: 25451265
Data indicate that malectin functions by forming a complex with ribophorin I. PMID: 22988243
ribophorin I can regulate the delivery of precursor proteins to the OST complex by capturing substrates and presenting them to the catalytic core. PMID: 18607003

Subcellular Location

Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Families

OST1 family

Tissue Specificity

Expressed in all tissues tested.

Database Links

HGNC: 10381

OMIM: 180470

KEGG: hsa:6184

STRING: 9606.ENSP00000296255

UniGene: Hs.518244

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Protein processing in endoplasmic reticulum

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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