RTN1 Antibody

Code CSB-PA020568GA01HU
Size US$685
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Product Details

Uniprot No. Q16799
Target Names RTN1
Alternative Names Neuroendocrine specific protein antibody; Neuroendocrine-specific protein antibody; NSP antibody; Reticulon 1 antibody; Reticulon-1 antibody; RTN 1 antibody; RTN1 antibody; RTN1_HUMAN antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human RTN1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Gene References into Functions
  1. Data suggest that reticulon 1A (RTN1A) functions not only as an endoplasmic reticulum-shaping protein but also as a protein that promotes contacts between endoplasmic reticulum and mitochondria. PMID: 28760823
  2. Results suggest evidence of genetic association between common variants in RTN1 and end-stage kidney disease in African-Americans and European-Americans. PMID: 26496126
  3. RTN1A is a key mediator for proteinuria-induced tubular cell toxicity and renal fibrosis. PMID: 26739891
  4. RTN1A contributes to progression of kidney disease by inducing ER stress. PMID: 26227493
  5. MANF is a protein that interacts with RTN1-C PMID: 25543119
  6. RTN-1C involvement in the regulation of Endoplasmic reticulum-mitochondria cross-talk, defines a role for RTN-1C in maintaining the function of contacts between the two organelles. PMID: 25573430
  7. RTN1-C induces PDI redistribution in endoplasmic reticulum vesicles, and concomitantly modulates its activity by decreasing the levels of its S-nitrosylated form. PMID: 23559015
  8. In the present study a potential metal ion binding motif (HxE/D) at the C-terminal of the RTN1-C has been identified and its capability to bind metals investigated by UV-vis, CD, multidimensional NMR spectroscopy and biological assays. PMID: 22522967
  9. RTN-1C is able to specifically regulate gene expression, modulating transcript clusters which have been implicated in the onset of neurodegenerative disorders PMID: 20708685
  10. RTN1-A and RTN1-B share N-terminal 168 amino acid region, suggesting that the 168 amino acid region might play a role in regulating the endocytic process PMID: 14995077
  11. Data demonstrate that reticulon 1 interacts specifically with spastin. PMID: 16602018
  12. analyzed the endoplasmic reticulum (ER) localization signal of human RTN1-A. Mutant proteins lacking the first (39 residues) or second (36 residues) hydrophobic segment showed ER localization PMID: 17303085
  13. These data indicate that RTN-1C is able to modulate the cellular sensitivity to different apoptotic pathways representing a promising molecular target for new drug development. PMID: 17596210
  14. Nucleic acid binding of the RTN1-C C terminal region is reported with a view towards the functional role of a reticulon protein. PMID: 19140693
  15. RTN-1C protein binds to DNA and that its biological function is regulated by acetylation and is coupled to the inhibition of HDAC activity. PMID: 19668229

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Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein
Tissue Specificity Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
Database Links

HGNC: 10467

OMIM: 600865

KEGG: hsa:6252

STRING: 9606.ENSP00000267484

UniGene: Hs.368626

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