RYR3 Antibody, Biotin conjugated

Datasheet
Code CSB-PA020621LD01HU
Size US$299
Uniprot No. Q15413
Immunogen Recombinant Human Ryanodine receptor 3 protein (987-1147AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor), RYR3, HBRR
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Neuroscience
Target Names RYR3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.
Subcellular Location Sarcoplasmic reticulum membrane, Multi-pass membrane protein, Membrane, Multi-pass membrane protein, Microsome membrane, Multi-pass membrane protein, Sarcoplasmic reticulum
Protein Families Ryanodine receptor (TC 1.A.3.1) family, RYR3 subfamily
Tissue Specificity Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.
Database Links

HGNC: 10485

OMIM: 180903

KEGG: hsa:6263

STRING: 9606.ENSP00000373884

UniGene: Hs.709373

Pathway Calcium signaling pathway
Apelin signaling pathway

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