DFFA Antibody

Code CSB-PA006737GA01HU
Size US$685
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Product Details

Uniprot No. O00273
Target Names DFFA
Alternative Names A330085O09Rik antibody; Caspase activated deoxyribonuclease inhibitor short form antibody; DFF 1 antibody; DFF 45 antibody; DFF alpha antibody; DFF-45 antibody; DFF1 antibody; DFF35 antibody; DFF45 antibody; DFFA antibody; Dffa DNA fragmentation factor, alpha subunit antibody; DFFA_HUMAN antibody; DNA fragmentation factor 45 kDa subunit antibody; DNA Fragmentation Factor Alpha Subunit antibody; DNA fragmentation factor subunit alpha antibody; DNA fragmentation factor, 45 kD, alpha subunit antibody; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1 antibody; DNA fragmentation factor, 45kDa, alpha polypeptide antibody; DNA fragmentation factor, alpha subunit antibody; DNAation factor 45 kDa subunit antibody; H13 antibody; ICAD antibody; ICAD L antibody; ICAD S antibody; Inhibitor of CAD antibody; Inhibitor of Caspase Activated DNase antibody; MGC143066 antibody; OTTHUMP00000001903 antibody; OTTHUMP00000001904 antibody; RP23 121D17.3 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human DFFA,DFF45
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Inhibitor of the caspase-activated DNase (DFF40).
Gene References into Functions
  1. Glandular, menopause-independent DFF40, DFF45, and Bcl-2 overexpression may play an important role in the pathogenesis of endometrial polyps and benign endometrial hyperplasia PMID: 28914671
  2. evaluate the relative expression levels of miR-196a2 and three of its selected apoptosis-related targets; ANXA1, DFFA and PDCD4 in a sample of GI cancer patients PMID: 29091952
  3. Data show that the caspase-activated DNase (CAD) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis. PMID: 26106156
  4. Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer. PMID: 24277473
  5. ICAD deficiency was associated with severe genomic instability. PMID: 23451280
  6. mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim, Bcl-x, and ICAD in Pnn-depleted MCF-7 cells. PMID: 22454513
  7. The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause. PMID: 22378161
  8. study reveals a previously unrecognized function of miR-145 in DFF45 processing, which may underlie crucial aspects of cancer biology PMID: 20687965
  9. The heterodimer, DFF40-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions. PMID: 19882353
  10. DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma tumors PMID: 11870543
  11. NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity PMID: 12144788
  12. Hypoxia-induced cleavage of caspase-3 and DFF45/ICAD in human failed cardiomyocytes. PMID: 12181128
  13. subunit structures and stoichiometries in human cells before and after induction of apoptosis PMID: 12748178
  14. Hepatitis C virus core protein increases a steady-state level of ICAD protein, possibly through enhancing its promoter activity PMID: 14675622
  15. apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression PMID: 16432220
  16. plays an important and P53-independent role in maintaining chromosome stability and suppressing tumor development PMID: 16619042
  17. demonstrate the cellular mechanisms of neuronal cell degeneration induced via c-Jun-N-terminal kinases and caspase-dependent signaling PMID: 17645689
  18. C-terminal region of each subunit, DFF40 (RLKRK) and DFF45 (KRAR), is essential for nuclear accumulation of the DFF complex. PMID: 17938174
  19. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation. PMID: 17945178
  20. The highest level of DFF45 endometrial expression was found during the early secretory cycle phase, and significantly lower DFF45 expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase. PMID: 18292826
  21. identified a TATA-less region upstream of the transcription start site as a basal promoter of the ICAD gene. An E-Box motif, which binds transcription factors of the basic helix-loop-helix/leucine zipper family, is responsible for transcriptional activity PMID: 18500556
  22. MPP(+) did not change the total levels of c-Jun but enhanced phosphorylation of c-Jun at Ser73 and cleavage of DNA fragmentation factor 45, which were diminished by selegiline. PMID: 18805449
  23. A decreased level of DFF45 observed in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. PMID: 19535198

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Subcellular Location Cytoplasm
Database Links

HGNC: 2772

OMIM: 601882

KEGG: hsa:1676

STRING: 9606.ENSP00000366237

UniGene: Hs.484782

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