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The peptide corresponding to amino acids 16-685 of the human SARS-CoV-2 spike (S) glycoprotein is used to immunize rabbits to produce the S antibody. This SARS-CoV-2 S antibody is a polyclonal antibody and occurs as a Biotin-conjugated IgG. This biotin-conjugated SARS-CoV-2 S antibody can be used as the detection antibody in combination with HRP to amplify the signal for the detection of S protein in the ELISA analysis. It is purified by protein G and reaches up to 95% in purity. The target protein SARS-CoV-2 S protein mediates the recognition, viral attachment, and entry into host cells. As it exerts essential roles in viral infection and it exists at the viral surface, the SARS-CoV-2 S protein is one of the most important targets for COVID-19 vaccine and therapeutic research.
|Full Product Name||Rabbit anti-Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) S Polyclonal antibody|
S; 2; Spike glycoprotein; S glycoprotein; E2; Peplomer protein)
|Species Reactivity||Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)|
|Immunogen||Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa) (CSB-YP3324GMYa4)|
|Immunogen Species||Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)|
|Purification Method||>95%, Protein G purified|
|Concentration||It differs from different batches. Please contact us to confirm it.|
|Buffer||Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
|Troubleshooting and FAQs||Antibody FAQs|
|Storage||Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.|
|Lead Time||Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.|
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attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.; mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.; Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.; May down-regulate host tetherin (BST2) by lysosomal degradation, thereby counteracting its antiviral activity.
|Gene References into Functions||
|Subcellular Location||Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.|
|Protein Families||Betacoronaviruses spike protein family|