SARNP Antibody

Code CSB-PA070014
Size US$100
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Product Details

Uniprot No.
Target Names
SARNP
Alternative Names
Cytokine induced protein of 29 kDa antibody; Cytokine-induced protein of 29 kDa antibody; HCC 1 antibody; HCC1 antibody; HSPC316 antibody; Nuclear protein Hcc 1 antibody; Nuclear protein Hcc-1 antibody; Proliferation associated cytokine inducible protein CIP29 antibody; Proliferation-associated cytokine-inducible protein CIP29 antibody; SAP domain-containing ribonucleoprotein antibody; SARNP antibody; SARNP_HUMAN antibody; THO1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human CIP29.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Gene References into Functions
  1. Herein, the authors extend their previous research and provide evidence that ORF57 of human herpesvirus-8 interacts with CHTOP and CIP29, in contrast to POLDIP3. PMID: 27189710
  2. CIP29 appears to be a new cytokine regulated protein involved in normal and cancer cell proliferation. PMID: 11922608
  3. Hcc-1 plays a role in growth regulation and nucleic acids metabolism. PMID: 15338056
  4. CIP29 physically and functionally associates with DDX39, suggesting their cooperation in the RNA metabolism. PMID: 17196963
Subcellular Location
Nucleus. Nucleus speckle.
Tissue Specificity
Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.
Database Links

HGNC: 24432

OMIM: 610049

KEGG: hsa:84324

STRING: 9606.ENSP00000337632

UniGene: Hs.505676

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