SCNN1D Antibody

1. delta-ENaC expression is low in NCI-H441, Calu-3, and ATI cells and does not contribute to transepithelial sodium absorption PMID: 25677639
2. study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins PMID: 22505667
3. delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels. PMID: 22159085
4. These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination. PMID: 21741370
5. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. PMID: 21419751
6. CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC. PMID: 21562313
7. Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel. PMID: 20631247
8. delta ENaC is regulated by Murr1 PMID: 14645214
9. ENaCdelta activity is regulated by protons, and may contribute to the pH sensation and/or pH regulation in the human brain PMID: 14726523
10. ENaCdelta is chemically activated by capsazepine by a proton-dependent mechanism PMID: 15308635
11. analysis of anovel spliced variant of the ENaC delta-subunit in the human brain PMID: 16930535
12. ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei. PMID: 17472699
13. Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques. PMID: 18073141
14. ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease PMID: 18951889
15. the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity PMID: 19717556
16. delta ENaC is a proton sensor PMID: 15084585

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HGNC: 10601

OMIM: 601328

KEGG: hsa:6339

STRING: 9606.ENSP00000368411

UniGene: Hs.512681