Recombinant Human Amiloride-sensitive sodium channel subunit delta (SCNN1D), partial

Code CSB-YP020850HU
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Source Yeast
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Code CSB-EP020850HU
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Source E.coli
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Code CSB-EP020850HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP020850HU
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Source Baculovirus
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Code CSB-MP020850HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SCNN1D
Uniprot No.
Alternative Names
Amiloride sensitive sodium channel subunit delta; Amiloride-sensitive sodium channel subunit delta; Delta ENaC; Delta NaCH; Delta-ENaC; Delta-NaCH; DNACH; ENaC Delta; ENaCD; ENaCdelta; Epithelial Na(+) channel subunit delta; MGC149710; MGC149711; Nonvoltage gated sodium channel 1 subunit delta; Nonvoltage-gated sodium channel 1 subunit delta; SCNED; SCNN1D; SCNND_HUMAN; Sodium channel, nonvoltage gated 1, delta
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Gene References into Functions
  1. delta-ENaC expression is low in NCI-H441, Calu-3, and ATI cells and does not contribute to transepithelial sodium absorption PMID: 25677639
  2. study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins PMID: 22505667
  3. delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels. PMID: 22159085
  4. These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination. PMID: 21741370
  5. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. PMID: 21419751
  6. CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC. PMID: 21562313
  7. Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel. PMID: 20631247
  8. delta ENaC is regulated by Murr1 PMID: 14645214
  9. ENaCdelta activity is regulated by protons, and may contribute to the pH sensation and/or pH regulation in the human brain PMID: 14726523
  10. ENaCdelta is chemically activated by capsazepine by a proton-dependent mechanism PMID: 15308635
  11. analysis of anovel spliced variant of the ENaC delta-subunit in the human brain PMID: 16930535
  12. ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei. PMID: 17472699
  13. Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques. PMID: 18073141
  14. ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease PMID: 18951889
  15. the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity PMID: 19717556
  16. delta ENaC is a proton sensor PMID: 15084585

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1D subfamily
Database Links

HGNC: 10601

OMIM: 601328

KEGG: hsa:6339

STRING: 9606.ENSP00000368411

UniGene: Hs.512681

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