SEC61B Antibody

1. used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common polycystic liver disease genes, PRKCSH and SEC63, to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8, GANAB, and SEC61B. Similarly to PRKCSH and SEC63, these genes encode proteins that are integral to the protein biogenesis pathway in the endoplasmic reticulum. PMID: 28375157
2. Sec61beta overexpression increased tight junction modulation rates, in conjunction with enhanced delivery of claudin-4 from and to plasma membranes. PMID: 24882410
3. Sec61beta-KD cells also exhibited altered ATP7A cellular distribution. PMID: 22710939
4. SEC61beta and its autoantibody as biomarkers for colorectal cancer PMID: 21255561
5. Sec61beta function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR. PMID: 20937808
6. This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon. PMID: 17215517

Show More

Hide All

HGNC: 16993

OMIM: 609214

KEGG: hsa:10952

STRING: 9606.ENSP00000223641

UniGene: Hs.191887