SEL1L Antibody

1. In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L. PMID: 29371607
2. Silencing of SEL1L during infection also stabilized an interaction of gO with the ER lectin OS-9, which likewise suggests that gO is an ER-associated degradation (ERAD) substrate. Taken together, our results identify an intriguing interaction of UL148 with the ERAD machinery and demonstrate that gO behaves as a constitutive ERAD substrate during infection. PMID: 29997207
3. Together, these results suggest that ER stress might comprise an important factor in GCD2 pathophysiology and that the effects of 4-PBA treatment might have important implications for the development of GCD2 therapeutics. PMID: 27373828
4. The SEL1L critically regulates HRD1-mediated disposal of misfolded cargo through its short membrane spanning stretch. PMID: 26471130
5. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients PMID: 25948789
6. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma. PMID: 23661430
7. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function. PMID: 24324549
8. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties. PMID: 24311781
9. ATF6 represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature. PMID: 24043630
10. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP PMID: 23363602
11. SEL1L expression is a potential colorectal cancer (CRC) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC cancers PMID: 22350780
12. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers. PMID: 21656579
13. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells. PMID: 21359144
14. regulation of the stability and assembly of the HRD1-SEL1L complex is critical to optimize the degradation kinetics of ERAD substrates PMID: 21454652
15. Overexpression of SEL1L protein is likely an early event during the pathogenesis of esophageal squamous cell carcinoma. PMID: 17822620
16. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. PMID: 11809711
17. Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population. PMID: 12030374
18. Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture. PMID: 12553058
19. Region within SEL1L between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. PMID: 14729273
20. SEL1L has a very complex structure consisting of 21 exons featuring several alternative transcripts encoding for putative protein isoforms. Its complexity ensures protein flexibility and specificity. PMID: 16331677
21. SEL1L alters the expression of mediators involved in the remodeling of the extracellular matrix by creating a microenvironment that is unfavorable to invasive growth. PMID: 16331889
22. A possible role of the novel polymorphism as independent susceptibility factor of Alzheimer's dementia is shown PMID: 16412574
23. endoplasmic reticulum stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively PMID: 17967421
24. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD PMID: 18264092
25. These findings reveal a role for SEL1L and HRD1 in IgM quality control. PMID: 18314878
26. XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP PMID: 18502753
27. identified AUP1, UBXD8, UBC6e, and OS9 as functionally important components of this degradation complex formed by proteins that interact with SEL1L PMID: 18711132
28. knockdown of SEL1L [sel-1 suppressor of lin-12-like (Caenorhabditis elegans)], a member of an E3 ubiquitin ligase complex involved in ER protein extraction, rescued significant amounts of Cln6(G123D) and Cln6(M241T) polypeptides. PMID: 18811591
29. SEL1L-B and -C participate to novel molecular pathways that, in parallel with ERAD, contribute to the disposure of misfolded/unfolded or orphan proteins through degradation or secretion PMID: 19204006

Show More

Hide All

HGNC: 10717

OMIM: 602329

KEGG: hsa:6400

STRING: 9606.ENSP00000337053

UniGene: Hs.181300