SEL1L Antibody

Code CSB-PA866208LA01HU
Size US$166
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  • IHC image of CSB-PA866208LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA866208LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA866208LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SEL1L Polyclonal antibody
Uniprot No.
Target Names
SEL1L
Alternative Names
IBD2 antibody; PRO1063 antibody; Protein sel-1 homolog 1 antibody; SE1L1_HUMAN antibody; Sel 1 like protein antibody; Sel 1 suppressor of lin 12 like antibody; Sel-1L antibody; SEL1 LIKE antibody; Sel1l antibody; SEL1LIKE antibody; Suppressor of lin-12-like protein 1 antibody; TSA305 antibody; UNQ128 antibody; UNQ128/PRO1063 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein sel-1 homolog 1 protein (22-181AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SEL1L Antibody (Product code: CSB-PA866208LA01HU) is Non-conjugated. For SEL1L Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA866208LB01HU SEL1L Antibody, HRP conjugated ELISA
FITC CSB-PA866208LC01HU SEL1L Antibody, FITC conjugated
Biotin CSB-PA866208LD01HU SEL1L Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Gene References into Functions
  1. In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L. PMID: 29371607
  2. Silencing of SEL1L during infection also stabilized an interaction of gO with the ER lectin OS-9, which likewise suggests that gO is an ER-associated degradation (ERAD) substrate. Taken together, our results identify an intriguing interaction of UL148 with the ERAD machinery and demonstrate that gO behaves as a constitutive ERAD substrate during infection. PMID: 29997207
  3. Together, these results suggest that ER stress might comprise an important factor in GCD2 pathophysiology and that the effects of 4-PBA treatment might have important implications for the development of GCD2 therapeutics. PMID: 27373828
  4. The SEL1L critically regulates HRD1-mediated disposal of misfolded cargo through its short membrane spanning stretch. PMID: 26471130
  5. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients PMID: 25948789
  6. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma. PMID: 23661430
  7. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function. PMID: 24324549
  8. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties. PMID: 24311781
  9. ATF6 represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature. PMID: 24043630
  10. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP PMID: 23363602
  11. SEL1L expression is a potential colorectal cancer (CRC) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC cancers PMID: 22350780
  12. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers. PMID: 21656579
  13. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells. PMID: 21359144
  14. regulation of the stability and assembly of the HRD1-SEL1L complex is critical to optimize the degradation kinetics of ERAD substrates PMID: 21454652
  15. Overexpression of SEL1L protein is likely an early event during the pathogenesis of esophageal squamous cell carcinoma. PMID: 17822620
  16. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. PMID: 11809711
  17. Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population. PMID: 12030374
  18. Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture. PMID: 12553058
  19. Region within SEL1L between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. PMID: 14729273
  20. SEL1L has a very complex structure consisting of 21 exons featuring several alternative transcripts encoding for putative protein isoforms. Its complexity ensures protein flexibility and specificity. PMID: 16331677
  21. SEL1L alters the expression of mediators involved in the remodeling of the extracellular matrix by creating a microenvironment that is unfavorable to invasive growth. PMID: 16331889
  22. A possible role of the novel polymorphism as independent susceptibility factor of Alzheimer's dementia is shown PMID: 16412574
  23. endoplasmic reticulum stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively PMID: 17967421
  24. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD PMID: 18264092
  25. These findings reveal a role for SEL1L and HRD1 in IgM quality control. PMID: 18314878
  26. XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP PMID: 18502753
  27. identified AUP1, UBXD8, UBC6e, and OS9 as functionally important components of this degradation complex formed by proteins that interact with SEL1L PMID: 18711132
  28. knockdown of SEL1L [sel-1 suppressor of lin-12-like (Caenorhabditis elegans)], a member of an E3 ubiquitin ligase complex involved in ER protein extraction, rescued significant amounts of Cln6(G123D) and Cln6(M241T) polypeptides. PMID: 18811591
  29. SEL1L-B and -C participate to novel molecular pathways that, in parallel with ERAD, contribute to the disposure of misfolded/unfolded or orphan proteins through degradation or secretion PMID: 19204006

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Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein Families
Sel-1 family
Tissue Specificity
Highly expressed in pancreas.
Database Links

HGNC: 10717

OMIM: 602329

KEGG: hsa:6400

STRING: 9606.ENSP00000337053

UniGene: Hs.181300

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