SEMA4C Antibody

Code CSB-PA863177DSR2HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA863177DSR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA863177DSR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SEMA4C Polyclonal antibody
Uniprot No.
Target Names
SEMA4C
Alternative Names
KIAA1739 antibody; M-SEMA-F antibody; S4c antibody; SEM4C_HUMAN antibody; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C antibody; SEMA4C antibody; SEMACL1 antibody; SEMAF antibody; SEMAI antibody; Semaphorin-4C antibody; UNQ5855/PRO34487 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Semaphorin-4C protein (749-833AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Gene References into Functions
  1. Tumor-associated LECs produce sSEMA4C to promote lymphatic metastasis of tumors. PMID: 27401250
  2. ectopic expression of miR-25-3p reversed the epithelial-mesenchymal transition phenotype and sensitized cisplatin-resistant cervical cancer cells to cisplatin via targeting Sema4C PMID: 27743413
  3. Data show that G-protein-coupled receptor kinase-interacting protein 1 (GIT1) and semaphorin 4C (SEMA4C) were found to have putative microRNA miR-138 binding sites in their 3' untranslated region (3'UTRs). PMID: 26283050
  4. Suggest that up-regulation of miR-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers. PMID: 25605244
  5. Data suggest that Erbin can interact with Sema4C, and co-expression of Erbin blocks the process of Sema4C-induced epithelial-mesenchymal transition. PMID: 24142719
  6. There is a high expression of Sema4C in esophageal cancer, gastric cancer and rectal cancer, and expression is strongly correlated with lymphatic metastasis. PMID: 22944267
  7. High Sema4C is associated with epithelial-mesenchymal transition and renal fibrosis. PMID: 20959347

Show More

Hide All

Subcellular Location
Cell junction, synapse, postsynaptic density membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.
Protein Families
Semaphorin family
Database Links

HGNC: 10731

OMIM: 604462

KEGG: hsa:54910

STRING: 9606.ENSP00000306844

UniGene: Hs.516220

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*