SERPINA5 Antibody

1. the snp rs1955656 in the SERPINA5 were associated with the development of severe acute kidney injury (KDIGO stage 2-3) in critically ill patients with septic shock PMID: 28270177
2. Data show that the methylation degree of five CpG sites significantly correlated with lower SERPINA5 expression levels. PMID: 29187436
3. We confirmed associations with papillary thyroid cancer and SNPs in FOXE1/HEMGN, SERPINA5 (rs2069974), FTO (rs8047395), EVPL (rs2071194), TICAM1 (rs8120) and SCARB1 (rs11057820) genes. We found associations with SNPs in FOXE1, SERPINA5, FTO, TICAM1 and HSPA6 and and follicular thyroid cancer PMID: 27207655
4. host protein C inhibitor expressed in mouse has a role in inhibiting tumor growth, but promotes tumor metastasis, which is closely correlated with hypercoagulability PMID: 25887633
5. These findings highlight an important role of SERPINA5 in the regulation of migratory and metastatic potentials of HCC and suggest a potential application of SERPINA5 in cancer treatment. PMID: 24388360
6. These results suggest that HIV resistance in some exposed patients is the result of a balance between downregulation of serine proteinases and upregulation of their inhibitors. PMID: 24928035
7. A novel protein C inhibitor gene mutation in pediatric stroke patients after bone marrow transplantation. PMID: 23670045
8. Decreased SERPINA5 expression due to DNA promoter methylation is associated with papillary thyroid carcinoma. PMID: 24222120
9. the SERPINA5 gene, which codes for the protein C inhibitor involved in many biological processes including inflammation, may be a new susceptibility locus for PTC. PMID: 23520464
10. One of the monomers, 52-kDa PCI, formed a stable complex with activated protein C, urokinase, plasma and tissue kallikrein, but the dimer species and 48-kDa PCI were inactive. PMID: 22206708
11. the effects of N-glycans and the NH-terminus on a PCI function PMID: 22205989
12. SerpinA5 expression is significantly reduced in advanced-stage serous borderline tumors and serous carcinomas. PMID: 21102419
13. This study was undertaken to further understand the structural micro-heterogeneity of PCI. Individuals of two different ethnicities possess a similar PCI pattern, verifying that the micro-heterogeneity is conserved among humans. PMID: 21056543
14. APC-PCI complex levels were higher in peripheral arterial disease patients than in controls, but did not predict the clinical outcome. PMID: 20409682
15. function for PCI in innate immunity PMID: 20019810
16. In men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0). PMID: 19765701
17. PCI can up regulate TAFI activation by inhibiting the protein C activation. PCI may therefore be an important regulator in the balance between coagulation and fibrinolysis by differentially inhibiting the activation of TAFI and of protein C. PMID: 11686324
18. Role of each Asn-linked glycan in the anticoagulant activity of human protein C inhibitor. PMID: 11864713
19. Protein C inhibitor regulates the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by these cells PMID: 14696115
20. PCI may be involved in regulating key serine proteases involved in metastatic prostate disease PMID: 15878512
21. exposure of oxidized PE and/or PS may be important for the local regulation of protein C inhibitor activity in vivo PMID: 17332248
22. anti-angiogenic activity of PCI was strong as cleaved antithrombin, and slightly stronger than that of plasminogen activator inhibitor-1 and pigment epithelium-derived factor PMID: 17450526
23. Patients with abdominal aortic aneurysm have increased thrombin generation reflected by an increase in the activated protein C-protein C inhibitor complex, which correlates with aneurysm size. PMID: 18184931
24. In human renal tissues, PCI and urinary plasminogen activator colocalized in the cytoplasm of renal proximal tubular epithelial cells PMID: 18193533
25. A crystallographic structure of the Michaelis complex of PCI, thrombin, and heparin to 1.6 A resolution, was determined. PMID: 18362344
26. The heparin binding site of protein C inhibitor is protease-dependent. PMID: 18974053

Show More

Hide All

HGNC: 8723

OMIM: 601841

KEGG: hsa:5104

STRING: 9606.ENSP00000333203

UniGene: Hs.159628