SH3GL1 Antibody

1. Study observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with TNF-alpha in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. PMID: 29113429
2. Our study provides novel evidence of Endo II function in HER2+ cancer cell motility and trafficking of HER2 that relates to effective treatments with trastuzumab or T-DM1. Thus, differential expression of Endo II may relate to sensitivity or resistance to trastuzumab-based therapies for HER2+ cancers PMID: 28974266
3. Expression level of SH3GL1 was widely upregulated in human OS tissues, and their overexpression was significantly correlated with more aggressive clinicopathological features. PMID: 28702842
4. Endophilin-A2 was identified as a novel molecule regulating macrophage-derived foam cell formation by mechanisms attributable to clathrin-mediated endocytosis and beyond clathrin-mediated endocytosis PMID: 27741419
5. inhibition of SH3GL1 reverses multidrug resistance through declining P-glycoprotein expression via the EGFR/ERK/AP-1 pathway. PMID: 27220321
6. Endo II expression was highest in triple-negative breast cancers tumors compared with other subtypes, and at the level of gene expression, high Endo II was associated with reduced relapse-free survival in patients with basal-like breast cancers. PMID: 25784716
7. results establish a novel function of endoA2 in clathrin-independent endocytosis PMID: 25517096
8. these data suggest that EEN may play a pivotal role in excessive cell proliferation and insufficient cell apoptosis of bone marrow plasma cells in multiple myeloma. PMID: 24704450
9. MIR218 functions as a tumor suppressor by regulating SH3GL1 expression in medulloblastoma cancer cells. PMID: 23970061
10. SH3GL1 may be involved in the oncogenic process of gliomas and effectively elicit an autologous antibody response in low-grade gliomas. PMID: 23050879
11. Two endophilin A2 mutants, E264A and E264R, have different effects on how endophilin interacts with other proteins, such as dynamin or beta1-adrenergic receptors. PMID: 22750032
12. Idiopathic scoliosis is a multifactorial genetic disease and SH3GL1 may be one of the pathogenic genes for this disease. PMID: 22183150
13. SH3GL1 is possibly one of the disease associated genes of adolescent idiopathic scoliosis. PMID: 20627007
14. new mechanism for MLL-EEN-mediated leukemogenesis in which MLL-EEN interferes with the Ras-suppressing activities of EBP through direct interaction. PMID: 14551139
15. EEN part plays an essential role in leukemogenesis caused by MLL-EEN. PMID: 15077184
16. Our results suggest that distinct subcellular localization of the endophilin A family members probably underpins their diverse cellular functions and indicates a role for EEN/EA2 in the cell cycle. PMID: 15214844
17. findings reveal a concomitant activation of endocytosis and ERK signaling by BPGAP1 via the coupling of its proline-rich region, which targets EEN and its functional GAP domain PMID: 15944398

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HGNC: 10830

OMIM: 601768

KEGG: hsa:6455

STRING: 9606.ENSP00000269886

UniGene: Hs.490415