SHC3 Antibody

1. High SHC3 expression is associated with glioblastoma. PMID: 25062668
2. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. PMID: 22311806
3. Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. PMID: 21046104
4. amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo. PMID: 19748727
5. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. PMID: 11877420
6. ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. PMID: 12185581
7. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 12242309
8. ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells PMID: 15735675
9. The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells. PMID: 15870690
10. data suggest that RAI (ShcC/H-Shc)is a critical substrate for RET oncoproteins in thyroid carcinomas PMID: 15940252
11. 11 SNPs within SHC3 were examined to determine the association with nicotine dependence (ND) in either African-Americans (AA) or European-Americans (EA); three SNPs for AAs and one for EAs were significantly associated with at least one ND. PMID: 17179996
12. shcc is expressed in the human gut, especially in the enteric glial cells PMID: 17919311
13. ShcC is a therapeutic target that might induce differentiation in the aggressive type of neuroblastomas. PMID: 18997821

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HGNC: 18181

OMIM: 605263

KEGG: hsa:53358

STRING: 9606.ENSP00000364995

UniGene: Hs.292737