SHC3 Antibody

Code CSB-PA838779LA01HU
Size US$166
Order now
Image
  • Western Blot
    Positive WB detected in: U87 whole cell lysate, Mouse lung tissue
    All lanes: SHC3 antibody at 3μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 65, 52 kDa
    Observed band size: 65 kDa

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SHC3 Polyclonal antibody
Uniprot No.
Target Names
SHC3
Alternative Names
N SHC antibody; N-Shc antibody; Neuronal Shc antibody; NSHC antibody; Protein Rai antibody; Rai antibody; SH2 domain protein C3 antibody; SHC (Src homology 2 domain containing) transforming protein 3 antibody; SHC adaptor protein 3 antibody; SHC protein C antibody; SHC-like protein, neuronal antibody; SHC-transforming protein 3 antibody; SHC-transforming protein C antibody; Shc3 antibody; Shc3 p51 antibody; SHC3_HUMAN antibody; SHCC antibody; Src homology 2 domain-containing transforming protein antibody; Src homology 2 domain-containing-transforming protein C3 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human SHC-transforming protein 3 protein (323-468AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SHC3 Antibody (Product code: CSB-PA838779LA01HU) is Non-conjugated. For SHC3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA838779LB01HU SHC3 Antibody, HRP conjugated ELISA
FITC CSB-PA838779LC01HU SHC3 Antibody, FITC conjugated
Biotin CSB-PA838779LD01HU SHC3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Gene References into Functions
  1. High SHC3 expression is associated with glioblastoma. PMID: 25062668
  2. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. PMID: 22311806
  3. Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment. PMID: 21046104
  4. amplification of SHC3 and EDG3 genes suggests that the two proteins co-operate and are important for ependymomas in vivo. PMID: 19748727
  5. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. PMID: 11877420
  6. ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase. PMID: 12185581
  7. The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 12242309
  8. ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells PMID: 15735675
  9. The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells. PMID: 15870690
  10. data suggest that RAI (ShcC/H-Shc)is a critical substrate for RET oncoproteins in thyroid carcinomas PMID: 15940252
  11. 11 SNPs within SHC3 were examined to determine the association with nicotine dependence (ND) in either African-Americans (AA) or European-Americans (EA); three SNPs for AAs and one for EAs were significantly associated with at least one ND. PMID: 17179996
  12. shcc is expressed in the human gut, especially in the enteric glial cells PMID: 17919311
  13. ShcC is a therapeutic target that might induce differentiation in the aggressive type of neuroblastomas. PMID: 18997821

Show More

Hide All

Tissue Specificity
Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, me
Database Links

HGNC: 18181

OMIM: 605263

KEGG: hsa:53358

STRING: 9606.ENSP00000364995

UniGene: Hs.292737

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*