SHC4 Antibody

Datasheet

Code	CSB-PA747568ESR1HU
Size	US$166
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Image	Western blot All lanes: SHC4 antibody at 6μg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 69, 43 kDa Observed band size: 69 kDa Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA747568ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SHC4 Polyclonal antibody

Uniprot No.

Q6S5L8

Target Names

SHC4

Alternative Names

hShcD antibody; MGC34023 antibody; Rai like protein antibody; Rai-like protein antibody; RaLP antibody; SH2 domain protein C4 antibody; SHC (Src homology 2 domain containing) family member 4 antibody; SHC 4 antibody; SHC adaptor protein 4 antibody; SHC antibody; SHC family member 4 antibody; SHC transforming protein 4 antibody; SHC transforming protein D antibody; SHC-transforming protein 4 antibody; SHC-transforming protein D antibody; Shc4 antibody; SHC4_HUMAN antibody; SHCD antibody; Src homology 2 domain containing family member 4 antibody; Src homology 2 domain containing transforming protein C4 antibody; Src homology 2 domain-containing-transforming protein C4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human SHC-transforming protein 4 protein (1-185AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

Gene References into Functions

ShcD appears to possess several molecular permutations that actively govern the EGFR, which may have implications in development and disease. PMID: 28724758
ShcD binds to active Ret, TrkA, and TrkB neurotrophic factor receptors predominantly via its phosphotyrosine-binding (PTB) domain. PMID: 28213521
The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor. PMID: 24430869
ShcD can exist within the nucleus, and its CH2 domain has a critical role in nuclear export of ShcD. PMID: 24036217
ShcD binds to TrkC in a kinase-activity-dependent manner through its PTB and SH2 domains. PMID: 20078941
ShcD interacts with TrkB in a kinase-activity-dependent manner. PMID: 20663410
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
A new member of the Shc family of docking proteins is characterised, which may mediate a specific aspect of signaling downstream of the MuSK receptor. PMID: 17452444

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Subcellular Location

Cell junction, synapse, postsynaptic cell membrane.

Tissue Specificity

Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive

Database Links

HGNC: 16743

OMIM: 617372

KEGG: hsa:399694

STRING: 9606.ENSP00000329668

UniGene: Hs.642615

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Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Chemokine signaling pathway ErbB signaling pathway Estrogen signaling pathway Focal adhesion Ras signaling pathway Natural killer cell mediated cytotoxicity Insulin signaling pathway Phospholipase D signaling pathway Neurotrophin signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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