SIGIRR Antibody

Code CSB-PA743558ESR1HU
Size US$166
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  • Western blot
    All lanes: SIGIRR antibody at 1.77µg/ml
    Lane 1: Mouse liver tissue
    Lane 2: Mouse kidney tissue
    Lane 3: MCF-7 whole cell lysate
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 46, 56 kDa
    Observed band size: 46 kDa

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA743558ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA743558ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SIGIRR Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Ig IL1 related receptor antibody; MGC110992 antibody; SIGIR_HUMAN antibody; SIGIRR antibody; Single Ig IL 1 related receptor antibody; Single Ig IL-1-related receptor antibody; Single Ig IL-1R-related molecule antibody; Single Ig IL1R Related Molecule antibody; Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody; Single immunoglobulin and toll interleukin 1 receptor domain antibody; Single immunoglobulin domain containing IL1R related protein antibody; Single immunoglobulin domain IL1R1 related antibody; Single immunoglobulin domain-containing IL1R-related protein antibody; TIR 8 antibody; TIR8 antibody; Toll/interleukin 1 receptor 8 antibody; Toll/interleukin-1 receptor 8 antibody
Raised in
Species Reactivity
Human, Mouse
Recombinant Human Single Ig IL-1-related receptor protein (1-120AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Gene References into Functions
  1. SIGIRR is both a negative regulator of TLR4 and a positive regulator of TLR7/8. PMID: 28869081
  2. Our results indicate that high IL-1R8 expression acts as a novel immunomodulatory mechanism leading to dysregulated immunity with important implications for breast cancer immunotherapy. PMID: 28533483
  3. show by flow cytometry analysis, western blot, confocal microscopy, and quantitative real-time polymerase chain reaction that IL-1R8 is expressed on human and mouse platelets at high levels and on megakaryocytes. IL-1R8-deficient mice show normal levels of circulating platelets PMID: 27297888
  4. Tir8/SIGIRR acts anti-inflammatory on different immune responses,its function in allergic asthma is a controversial issue, since anti- as well as pro-inflammatory effects have been reported PMID: 26561030
  5. SIGIRR plays an important role in the negative regulation of LPS response and tolerance in human bladder epithelial cells, possibly through its impact on TLR-mediated signaling. PMID: 26634342
  6. Levels of SIGIRR are lower in human colorectal tumors, compared with nontumor tissues; tumors contain the dominant-negative isoform SIGIRR(DeltaE8). PMID: 26344057
  7. SIGIRR predicts biochemical recurrence in patients with low Gleason score and low pathological stage prostate cancer. PMID: 26344417
  8. decreased numbers of SIGIRR-positive CD4+ T cells in SLE patients and its correlation with SLEDAI score as well as the clinical data suggest that SIGIRR may be involved in the pathogenesis of SLE. PMID: 25287661
  9. To the best of our knowledge, this is one of the first reports of a phenotype associated with SIGIRR in humans. Our data provide novel mechanistic insight into the probable causation of necrotizing enterocolitis PMID: 25963006
  10. An association was found in the SIGIRR rs7396562 polymorphism and systemic lupus erythematosus susceptibility in a Chinese population. PMID: 24826913
  11. IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. PMID: 25729923
  12. IL-37 acts as an extracellular cytokine by binding to the IL-18 receptor but using the IL-1R8 for its anti-inflammatory properties. PMID: 25654981
  13. Lipopolysaccharide decreases SIGIRR expression by suppressing specificity protein 1 Sp1 via the TLR4-p38 pathway in monocytes and neutrophils. PMID: 24821721
  14. the tested variations of IRAK-M and SIGIRR genes do not confer a relevant role in the susceptibility to systemic lupus erythematosus in European-descent populations PMID: 22634523
  15. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts. PMID: 22223854
  16. These results suggest that PALM3 may function as an adaptor in the LPS- Toll-like receptor 4 signaling and the interaction of SIGIRR with PALM3 may partly account for the mechanism of the negatively regulatory effect of SIGIRR. PMID: 21187075
  17. SIGIRR is expressed constitutively in intestinal epithelial cells to maintain gut innate immunity and then down-regulated during inflammation by inhibition of an SP1-mediated pathway. PMID: 21077278
  18. SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis PMID: 20506350
  19. regulatory functions in inflammation and Th1/Th2 cell polarization (Review) PMID: 19699681
  20. SIGIRR inhibits IL-1R and TLR4-mediated signaling through different mechanisms PMID: 15866876

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Subcellular Location
Membrane; Single-pass type III membrane protein.
Protein Families
Interleukin-1 receptor family
Tissue Specificity
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Database Links

HGNC: 30575

OMIM: 605478

KEGG: hsa:59307

STRING: 9606.ENSP00000333656

UniGene: Hs.501624

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