gen like family member B antibody; bA77C3.1 antibody; CD172 antigen-like family member B antibody; CD172g antibody; CD172g antigen antibody; FLJ42230 antibody; RP11-77C3.2 antibody; Signal regulatory protein beta 2 antibody; Signal regulatory protein gamma antibody; Signal-regulatory protein beta-2 antibody; Signal-regulatory protein gamma antibody; SIRP B2 antibody; SIRP beta 2 antibody; SIRP gamma antibody; SIRP-b2 antibody; SIRP-beta-2 antibody; SIRP-gamma antibody; SIRPB2 antibody; SIRPG antibody; SIRPG_HUMAN antibody; SIRPgamma antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human SIRPG
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Gene References into Functions
SIRPgamma in complex with FabOX117 forms a dimer in the crystal. Binding to the Fab fixes the position of domain 1 relative to domains 2/3 exposing a surface which favours formation of a homotypic dimer. PMID: 23826770
The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG. PMID: 24162948
a novel member of the signal regulatory protein (SIRP) family- with unique characteristics from both alpha and beta genes- termed SIRPgamma PMID: 15294972
CD47 is enriched at endothelial junctions, and its interaction with SIRPgamma is required for human T-cell transendothelial migration PMID: 18524990
tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus. PMID: 19473566
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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the