SIRPG Antibody

Code CSB-PA021338ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SIRPG Polyclonal antibody
Uniprot No.
Target Names
SIRPG
Alternative Names
gen like family member B antibody; bA77C3.1 antibody; CD172 antigen-like family member B antibody; CD172g antibody; CD172g antigen antibody; FLJ42230 antibody; RP11-77C3.2 antibody; Signal regulatory protein beta 2 antibody; Signal regulatory protein gamma antibody; Signal-regulatory protein beta-2 antibody; Signal-regulatory protein gamma antibody; SIRP B2 antibody; SIRP beta 2 antibody; SIRP gamma antibody; SIRP-b2 antibody; SIRP-beta-2 antibody; SIRP-gamma antibody; SIRPB2 antibody; SIRPG antibody; SIRPG_HUMAN antibody; SIRPgamma antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens
Immunogen
Recombinant Homo sapiens SIRPG protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Gene References into Functions
  1. SIRPgamma in complex with FabOX117 forms a dimer in the crystal. Binding to the Fab fixes the position of domain 1 relative to domains 2/3 exposing a surface which favours formation of a homotypic dimer. PMID: 23826770
  2. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG. PMID: 24162948
  3. a novel member of the signal regulatory protein (SIRP) family- with unique characteristics from both alpha and beta genes- termed SIRPgamma PMID: 15294972
  4. CD47 is enriched at endothelial junctions, and its interaction with SIRPgamma is required for human T-cell transendothelial migration PMID: 18524990
  5. tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus. PMID: 19473566

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the
Database Links

HGNC: 15757

OMIM: 605466

KEGG: hsa:55423

STRING: 9606.ENSP00000305529

UniGene: Hs.590883

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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