SKAP2 Antibody

1. Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs. PMID: 26577701
2. Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement. PMID: 22976304
3. SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for Non-small cell lung cancer treatment. PMID: 25862907
4. results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2-cortactin complex PMID: 23161539
5. analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate PMID: 21719704
6. cloning & characterization of an adaptor protein that functions as a downstream target for RAFTK & plays a role in alpha-synuclein phosphorylation PMID: 12893833
7. studies provide insights into the molecular mechanism ofrelated adhesion focal tyrosine kinase (RAFTK) autophosphorylation and the specific role of Src in the regulation of RAFTK activation PMID: 15166227
8. Overexpression of SKAP2 is associated with the development of pancreatic ductal adenocarcinoma PMID: 17952125

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HGNC: 15687

OMIM: 605215

KEGG: hsa:8935

STRING: 9606.ENSP00000005587

UniGene: Hs.200770