SLC17A8 Antibody

1. Novel pathogenic splicing mutation in SLC17A8 gene identified in a family with hearing loss. PMID: 28647561
2. A point mutation in VGLUT3 dramatically reduces its expression in synaptic terminals without altering its function. PMID: 28314816
3. The results of this study identify VGLUT3 as an unexpected regulator of drug abuse. PMID: 26239290
4. The results from our study suggest that the p.M206Nfs*4 mutation in the SLC17A8 gene is likely a pathogenic mutation that causes autosomal dominant non-syndromic hearing loss. PMID: 26797701
5. The absence of VGLUT3 in transgenic mice leads to an up-regulation of the midbrain dopamine system and ameliorates motor dysfunction in a model of Parkinson's disease. PMID: 26558771
6. human vesicular glutamate transporter 3 was cloned, shows 72% identity to both hVGLUT1 and hVGLUT2, and its expression in brain overlaps with hVGLUT1 and hVGLUT2 PMID: 12151341
7. Docking and homology modeling explain the inhibition of VGLUT3. PMID: 17660252
8. VGLUT3 immunoreactivity covered only a limited portion of the possible Glu-ergic pathways in the human fetal small intestine. PMID: 18498073
9. SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction PMID: 18674745

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HGNC: 20151

OMIM: 605583

KEGG: hsa:246213

STRING: 9606.ENSP00000316909

UniGene: Hs.116871