SLC17A8 Antibody

Code CSB-PA107772
Size US$166
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  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue and Human cerebrum tissue lysates, Primary antibody: CSB-PA107772(SLC17A8 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC17A8 Polyclonal antibody
Uniprot No.
Target Names
SLC17A8
Alternative Names
Solute carrier family 17 (vesicular glutamate transporter), member 8; DFNA25; VGLUT3
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of human SLC17A8
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
Gene References into Functions
  1. Novel pathogenic splicing mutation in SLC17A8 gene identified in a family with hearing loss. PMID: 28647561
  2. A point mutation in VGLUT3 dramatically reduces its expression in synaptic terminals without altering its function. PMID: 28314816
  3. The results of this study identify VGLUT3 as an unexpected regulator of drug abuse. PMID: 26239290
  4. The results from our study suggest that the p.M206Nfs*4 mutation in the SLC17A8 gene is likely a pathogenic mutation that causes autosomal dominant non-syndromic hearing loss. PMID: 26797701
  5. The absence of VGLUT3 in transgenic mice leads to an up-regulation of the midbrain dopamine system and ameliorates motor dysfunction in a model of Parkinson's disease. PMID: 26558771
  6. human vesicular glutamate transporter 3 was cloned, shows 72% identity to both hVGLUT1 and hVGLUT2, and its expression in brain overlaps with hVGLUT1 and hVGLUT2 PMID: 12151341
  7. Docking and homology modeling explain the inhibition of VGLUT3. PMID: 17660252
  8. VGLUT3 immunoreactivity covered only a limited portion of the possible Glu-ergic pathways in the human fetal small intestine. PMID: 18498073
  9. SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction PMID: 18674745

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Involvement in disease
Deafness, autosomal dominant, 25 (DFNA25)
Subcellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
Protein Families
Major facilitator superfamily, Sodium/anion cotransporter family, VGLUT subfamily
Tissue Specificity
Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.
Database Links

HGNC: 20151

OMIM: 605583

KEGG: hsa:246213

STRING: 9606.ENSP00000316909

UniGene: Hs.116871

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