SLC2A5 Antibody

Datasheet

Code	CSB-PA005624
Size	US$100
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Image	Western Blot analysis of K562 cells using Glut5 Polyclonal Antibody.
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Product Details
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Target Background

Product Details

Uniprot No.

P22732

Target Names

SLC2A5

Alternative Names

Facilitated glucose transporter member 5 antibody; Fructose transporter antibody; Glucose transporte; kidney antibody; Glucose Transporter 5 GLUT5 antibody; glucose transporter like protein 5 antibody; Glucose transporter type 5 antibody; Glucose transporter type 5 small intestine antibody; GLUT 5 antibody; GLUT-5 antibody; GLUT5 antibody; GTR5_HUMAN antibody; SLC 2A5 antibody; SLC2A5 antibody; small intestine antibody; solute carrier family 2 (facilitated glucose/fructose transporter); member 5 antibody; Solute carrier family 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the N-terminal region of Human Glut5.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxyglucose, but with low efficiency. Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake.

Gene References into Functions

identified amino acid residues of GLUT5 that define its substrate specificity for glucose transporter 5 (GLUT5)-mediated fructose transport. PMID: 29259131
fructose can be used by glioma cells, and restrict the fructose intake or targeting GLUT5 could be efficacious strategies in glioma. PMID: 29660339
SLC2A5-inhibits the human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network. PMID: 25326153
SGLT1 and GLUT5 expression in the plasma membrane is regulated by TNFalpha, leading to alteration on sugar transport, suggesting that TNFalpha could be a physiological local regulator of nutrient absorption in response to an intestinal inflammatory status. PMID: 23910014
[(99m)Tc]GLA uptake is related to GLUT-5 transporter expression and transport PMID: 23084044
A role for the GLUT5 isoform in fructose uptake that takes place in clear renal cell carcinoma cells and which subsequently leads to the malignant progression. PMID: 21165569
these results suggest that methylation of histone H3 at K4 and acetylation of histones H3 and H4 are involved in SLC2A5 gene induction associated with intestinal differentiation of Caco-2 cells. PMID: 20043883
Fructose modulation of GLUT5 mRNA stability via cyclic AMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. PMID: 12820898
GLUT5 expression is dramatically increased in diabetic muscle and pioglitazone treatment reverses this overexpression. PMID: 17251278
De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells. PMID: 18424253
These results suggest that the histone H3 di-methylation at lysine 9, as well as acetylation at lysine 9/14, may be indispensable for coordinated induction of the GLUT5 gene by p44/42 MAP kinase inhibition and the glucocorticoid hormone. PMID: 18439419
Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. PMID: 19091748

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Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma.

Protein Families

Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily

Tissue Specificity

Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Database Links

HGNC: 11010

OMIM: 138230

KEGG: hsa:6518

STRING: 9606.ENSP00000366641

UniGene: Hs.530003

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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