SLC30A7 Antibody, FITC conjugated

Datasheet

Code	CSB-PA836732LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC30A7 Polyclonal antibody

Uniprot No.

Q8NEW0

Target Names

SLC30A7

Alternative Names

SLC30A7; ZNT7; ZNTL2; Zinc transporter 7; ZnT-7; Solute carrier family 30 member 7; Znt-like transporter 2

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Zinc transporter 7 protein (162-236AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP.

Gene References into Functions

We observed Bonferroni-corrected statistically significant interactions between albuminuria, urine cadmium levels and polymorphisms in gene SLC30A7 and RAC1. PMID: 28558300
Overexpression of ZnT7 is accompanied by activation of PI3K/Akt pathway and inhibiting HG-induced apoptosis. PMID: 23275032
Intracellular transporters such as ZnT7, influence the transcellular movement of zinc across the enterocyte PMID: 21462106
hZnT-7 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
Data show that ZNT7 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746

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Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Protein Families

Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily

Database Links

HGNC: 19306

OMIM: 611149

KEGG: hsa:148867

STRING: 9606.ENSP00000350278

UniGene: Hs.533903

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