SLC33A1 Antibody

Code CSB-PA13339A0Rb
Size US$166
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Image
  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA13339A0Rb at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA13339A0Rb at dilution of 1:100

  • Western Blot
    Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
    All lanes: SLC33A1 antibody at 2.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 61 kDa
    Observed band size: 50 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC33A1 Polyclonal antibody
Uniprot No.
Target Names
SLC33A1
Alternative Names
ACATN antibody; ACATN_HUMAN antibody; Acetyl CoA transporter antibody; Acetyl Coenzyme A transporter antibody; Acetyl coenzyme A transporter 1 antibody; Acetyl-CoA transporter 1 antibody; Acetyl-coenzyme A transporter 1 antibody; AT 1 antibody; AT-1 antibody; AT1 antibody; Human Angiotensin II Type 1 Receptor antibody; Slc33a1 antibody; Solute carrier family 33 (acetyl CoA transporter) member 1 antibody; Solute carrier family 33 member 1 antibody; spastic paraplegia 42 (autosomal dominant) antibody; SPG42 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Acetyl-coenzyme A transporter 1 protein (1-74AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC33A1 Antibody (Product code: CSB-PA13339A0Rb) is Non-conjugated. For SLC33A1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA13339B0Rb SLC33A1 Antibody, HRP conjugated ELISA
FITC CSB-PA13339C0Rb SLC33A1 Antibody, FITC conjugated
Biotin CSB-PA13339D0Rb SLC33A1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
Gene References into Functions
  1. results indicate that increased expression of AT-1 can cause an autistic-like phenotype by affecting key neuronal metabolic pathways. PMID: 27242167
  2. SLC33A1 can negatively regulate BMP signaling. PMID: 25402622
  3. Homozygosity mapping displayed a region of commonality among three families at chromosome 3q25. Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1. PMID: 22243965
  4. translocates acetyl-CoA into the ER lumen and is essential for cell viability PMID: 20826464
  5. A missense mutation in SLC33A1 causes autosomal-dominant spastic paraplegia. PMID: 19061983

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Involvement in disease
Spastic paraplegia 42, autosomal dominant (SPG42); Congenital cataracts, hearing loss, and neurodegeneration (CCHLND)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
SLC33A transporter family
Tissue Specificity
Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
Database Links

HGNC: 95

OMIM: 603690

KEGG: hsa:9197

STRING: 9606.ENSP00000352456

UniGene: Hs.478031

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