SLC41A1 Antibody

Code CSB-PA810274LA01HU
Size US$166
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  • IHC image of CSB-PA810274LA01HU diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of HepG2 cells with CSB-PA810274LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC41A1 Polyclonal antibody
Uniprot No.
Target Names
SLC41A1
Alternative Names
SLC41A1 antibody; Solute carrier family 41 member 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Solute carrier family 41 member 1 protein (1-96AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC41A1 Antibody (Product code: CSB-PA810274LA01HU) is Non-conjugated. For SLC41A1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA810274LB01HU SLC41A1 Antibody, HRP conjugated ELISA
FITC CSB-PA810274LC01HU SLC41A1 Antibody, FITC conjugated
Biotin CSB-PA810274LD01HU SLC41A1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain.
Gene References into Functions
  1. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. PMID: 28222767
  2. The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of Parkinson's Disease was replicated in our population. PMID: 27612022
  3. Authors performed direct DNA sequencing of the SLC41A1 gene in 100 early-onset PD cases. PMID: 26308152
  4. Na+-dependent Mg2+ efflux conducted by Na+/Mg2+ exchanger SLC41A1 is regulated by insulin. PMID: 26355001
  5. This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese Parkinson disease. PMID: 24661466
  6. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas PMID: 23844728
  7. Binding partners of SLC41A1, were identified. PMID: 23823179
  8. Alanine350Valine substitution in Na/Mg(2) exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation. PMID: 23976986
  9. In normal human kidney tissue, endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary, consistent with the region of cystogenesis observed in nephronophthisis. PMID: 23661805
  10. Direct DNA sequencing of the SLC41A1 and RAB7L1 genes within the PARK16 locus in 205 Chinese Parkinson's disease patients shows no significant difference with controls. PMID: 21812739
  11. The human SLC41A1 gene encodes for the Na+/Mg(2)+ exchanger, the predominant Mg(2)+ efflux system. PMID: 22031603
  12. Results indicate that SLC41A1 proteins are a central component of Mg(2+) transport systems, and that their Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain. PMID: 21696366
  13. Observational study of gene-disease association. (HuGE Navigator) PMID: 20683486
  14. Data report the identification and structural characterization of solute carrier family 41 member 1 (SLC41A1), a eukaryotic protein with homology to the bacterial MgtE family of potential Mg(2+) transporters. PMID: 12810078
  15. The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. PMID: 15713785
  16. SLC41A1 is a novel mammalian Mg2+ carrier PMID: 18367447

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
SLC41A transporter family
Tissue Specificity
Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
Database Links

HGNC: 19429

OMIM: 610801

KEGG: hsa:254428

STRING: 9606.ENSP00000356105

UniGene: Hs.20274

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