Recombinant Human Solute carrier family 41 member 1 (SLC41A1), partial

Code CSB-YP810274HU
MSDS
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Source Yeast
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Code CSB-EP810274HU
MSDS
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Source E.coli
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Code CSB-EP810274HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP810274HU
MSDS
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Source Baculovirus
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Code CSB-MP810274HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC41A1
Uniprot No.
Alternative Names
SLC41A1; Solute carrier family 41 member 1
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane. Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump. Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day. Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain.
Gene References into Functions
  1. Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. PMID: 28222767
  2. The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of Parkinson's Disease was replicated in our population. PMID: 27612022
  3. Authors performed direct DNA sequencing of the SLC41A1 gene in 100 early-onset PD cases. PMID: 26308152
  4. Na+-dependent Mg2+ efflux conducted by Na+/Mg2+ exchanger SLC41A1 is regulated by insulin. PMID: 26355001
  5. This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese Parkinson disease. PMID: 24661466
  6. SLC41A1 is significantly overexpressed in nearly 55% of preeclamptic placentas PMID: 23844728
  7. Binding partners of SLC41A1, were identified. PMID: 23823179
  8. Alanine350Valine substitution in Na/Mg(2) exchanger SLC41A1, potentially associated with Parkinson's disease, is a gain-of-function mutation. PMID: 23976986
  9. In normal human kidney tissue, endogenous SLC41A1 specifically localized to renal tubules situated at the corticomedullary boundary, consistent with the region of cystogenesis observed in nephronophthisis. PMID: 23661805
  10. Direct DNA sequencing of the SLC41A1 and RAB7L1 genes within the PARK16 locus in 205 Chinese Parkinson's disease patients shows no significant difference with controls. PMID: 21812739
  11. The human SLC41A1 gene encodes for the Na+/Mg(2)+ exchanger, the predominant Mg(2)+ efflux system. PMID: 22031603
  12. Results indicate that SLC41A1 proteins are a central component of Mg(2+) transport systems, and that their Mg(2+) transport function is regulated primarily through an endosomal recycling mechanism involving the SLC41A1 N-terminal cytoplasmic domain. PMID: 21696366
  13. Observational study of gene-disease association. (HuGE Navigator) PMID: 20683486
  14. Data report the identification and structural characterization of solute carrier family 41 member 1 (SLC41A1), a eukaryotic protein with homology to the bacterial MgtE family of potential Mg(2+) transporters. PMID: 12810078
  15. The SLC41A1 transcript is present in many tissues, notably renal epithelial cells, and is upregulated in some tissues with magnesium deficiency. PMID: 15713785
  16. SLC41A1 is a novel mammalian Mg2+ carrier PMID: 18367447

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
SLC41A transporter family
Tissue Specificity
Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen.
Database Links

HGNC: 19429

OMIM: 610801

KEGG: hsa:254428

STRING: 9606.ENSP00000356105

UniGene: Hs.20274

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