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SLC9A8 Antibody

Datasheet
Code CSB-PA021739GA01HU
Size $600
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Product Details

Uniprot No.
Q9Y2E8
Target Names
SLC9A8
Alternative Names
Na(+)/H(+) exchanger 8 antibody; NHE 8 antibody; NHE-8 antibody; NHE8 antibody; SL9A8_HUMAN antibody; Slc9a8 antibody; Sodium/ hydrogen exchanger 8 antibody; Sodium/hydrogen exchanger 8 antibody; solute carrier family 9 (sodium/hydrogen exchanger); member 8 antibody; Solute carrier family 9 member 8 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SLC9A8
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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SLC9A8 antibodies

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Target Background

Function
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Gene References into Functions
  1. work has uncovered a crucial role of NHE8 in acrosome biogenesis and suggests that some forms of human globozoospermia might be caused by a loss of function of this Na(+)/H(+) exchanger. PMID: 28476888
  2. NHE8 is expressed in goblet cells, and the inflammatory cytokine TNF-alpha downregulates NHE8 expression by a transcriptional mechanism. PMID: 26564720
  3. Exonic mutations in NHE8 cannot account for congenital sodium diarrhea. PMID: 21666503
  4. These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology. PMID: 20719963
  5. EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription. PMID: 20375273
  6. NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms. PMID: 18209477
  7. Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity. PMID: 19109523

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Subcellular Location
Golgi apparatus membrane; Multi-pass membrane protein.
Protein Families
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Tissue Specificity
Ubiquitous. Strongly expressed in skeletal muscle and kidney.
Database Links

HGNC: 20728

OMIM: 612730

KEGG: hsa:23315

STRING: 9606.ENSP00000354966

UniGene: Hs.444202

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