SNRPD1 Antibody

Datasheet

Code	CSB-PA022332LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA022332LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA022332LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: HEK293 whole cell lysate All lanes: SNRPD1 antibody at 2.4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 14 kDa Observed band size: 14 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SNRPD1 Polyclonal antibody

Uniprot No.

P62314

Target Names

SNRPD1

Alternative Names

AA407109 antibody; AL023031 antibody; HsT2456 antibody; Sm D1 antibody; Sm-D autoantigen antibody; Sm-D1 antibody; Small nuclear ribonucleoprotein D1 polypeptide antibody; Small nuclear ribonucleoprotein Sm D1 antibody; SmD autoantigen antibody; SMD1 antibody; SMD1_HUMAN antibody; snRNP core protein D1 antibody; SNRPD antibody; Snrpd1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Small nuclear ribonucleoprotein Sm D1 protein (1-119AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SNRPD1 Antibody (Product code: CSB-PA022332LA01HU) is Non-conjugated. For SNRPD1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA022332LB01HU	SNRPD1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022332LC01HU	SNRPD1 Antibody, FITC conjugated
Biotin	CSB-PA022332LD01HU	SNRPD1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The CSB-PA022332LA01HU polyclonal antibody against SNRPD1 was generated in rabbits using recombinant human small nuclear ribonucleoprotein Sm D1 protein (1-119aa) as the immunogen. The resulting antibody was purified using protein G affinity chromatography and achieved a purity level of up to 95%.

This SNRPD1 polyclonal antibody is specific to human SNRPD1 proteins and can be utilized to identify the endogenous levels of SNRPD1 protein. Quality testing has been conducted for ELISA, WB, IHC, and IF applications, allowing users to detect, identify, and trace the SNRPD1 protein with this antibody.

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Target Background

Function

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.

Gene References into Functions

Data show that the elevation of cerebrospinal fluid anti-Sm antibodies through transudation from systemic circulation due to damaged blood-brain barrier (BBB) plays a critical role in the pathogenesis of acute confusional state (ACS). PMID: 25273532
The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
Overexpression of SNRPD1 is associated with highly aggressive breast cancers. PMID: 23358685

Subcellular Location

Cytoplasm, cytosol. Nucleus.

Protein Families

SnRNP core protein family

Database Links

HGNC: 11158

OMIM: 601063

KEGG: hsa:6632

STRING: 9606.ENSP00000300413

UniGene: Hs.464734

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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