SOCS5 Antibody

Code CSB-PA022394GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
SOCS5 antibody; CIS6 antibody; CISH5 antibody; CISH6 antibody; KIAA0671Suppressor of cytokine signaling 5 antibody; SOCS-5 antibody; Cytokine-inducible SH2 protein 6 antibody; CIS-6 antibody; Cytokine-inducible SH2-containing protein 5 antibody
Raised in
Species Reactivity
Human SOCS5
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Gene References into Functions
  1. These findings indicate that SOCS5 mediates the impaired function of dendritic cells in chronic lymphocytic leukemia patients PMID: 27317770
  2. Data show that the Japanese encephalitis virus (JEV)-induced expression of miR-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5). PMID: 28196914
  3. Here the authors show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). PMID: 28195529
  4. Opisthorchis felineus infection diminishes the risk of atopic bronchial asthma associated with the SOCS5 gene polymorphism. PMID: 25017311
  5. different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling with JAK1 and SHC-1 PMID: 23990909
  6. The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model and in dominant model PMID: 24340963
  7. Exogenous miR-9 effectively reduced SOCS5 levels, leading to activated JAK-STAT pathway, which promoted endothelial cell migration and tumour angiogenesis PMID: 22773185
  8. Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence. PMID: 22423360
  9. The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5. PMID: 15590694
  10. Constitutive expression of SOCS5 in transgenic mice results in reduced eosinophil infiltration in allergic conjunctivitis PMID: 16210657

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Database Links

HGNC: 16852

OMIM: 607094

KEGG: hsa:9655

STRING: 9606.ENSP00000305133

UniGene: Hs.468426

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