SOCS5 Antibody

1. These findings indicate that SOCS5 mediates the impaired function of dendritic cells in chronic lymphocytic leukemia patients PMID: 27317770
2. Data show that the Japanese encephalitis virus (JEV)-induced expression of miR-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5). PMID: 28196914
3. Here the authors show that suppressor of cytokine signaling (SOCS) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). PMID: 28195529
4. Opisthorchis felineus infection diminishes the risk of atopic bronchial asthma associated with the SOCS5 gene polymorphism. PMID: 25017311
5. different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling with JAK1 and SHC-1 PMID: 23990909
6. The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model and in dominant model PMID: 24340963
7. Exogenous miR-9 effectively reduced SOCS5 levels, leading to activated JAK-STAT pathway, which promoted endothelial cell migration and tumour angiogenesis PMID: 22773185
8. Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence. PMID: 22423360
9. The reduction in EGFR levels and EGF-induced signaling in SOCS5-expressing cells requires both the Src homology-2 and SOCS box domains of SOCS5. PMID: 15590694
10. Constitutive expression of SOCS5 in transgenic mice results in reduced eosinophil infiltration in allergic conjunctivitis PMID: 16210657

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HGNC: 16852

OMIM: 607094

KEGG: hsa:9655

STRING: 9606.ENSP00000305133

UniGene: Hs.468426