SPA17 Antibody

Code CSB-PA12124A0Rb
Size US$166
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Image
  • IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPA17 Polyclonal antibody
Uniprot No.
Target Names
SPA17
Alternative Names
Band 34 antibody; Cancer/testis antigen 22 antibody; CT22 antibody; SP17 1 antibody; Sp17-1 antibody; SP17_HUMAN antibody; SPA17 antibody; Sperm autoantigenic protein 17 antibody; Sperm protein 17 antibody; Sperm surface protein Sp17 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sperm surface protein Sp17 protein (1-146AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SPA17 Antibody (Product code: CSB-PA12124A0Rb) is Non-conjugated. For SPA17 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA12124B0Rb SPA17 Antibody, HRP conjugated ELISA
FITC CSB-PA12124C0Rb SPA17 Antibody, FITC conjugated
Biotin CSB-PA12124D0Rb SPA17 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.
Gene References into Functions
  1. Sp17 and ASP cancer/testis antigens were found in ciliated cells of four ciliated hepatic foregut cysts (CHFCs). Further characterization of Sp17 and ASP in patients with CHFCs may provide significant clues for understanding the molecular mechanisms underlying their predisposition to develop squamous cell carcinomas. PMID: 25600306
  2. dendritic cells from human umbilical cord blood modulated for SP17 expression induced antigen-specific anti-tumor immunity against SP17(+) non-small cell lung cancer. PMID: 26300426
  3. SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines and primary tumors and can elicit an immunogenic response in lung cancer patients. PMID: 25739119
  4. NY-ESO-1 and SP17 was not significantly associated with a specific histotype, but high-level GAGE expression was more frequent in squamous cell carcinoma. GAGE expression was demonstrated to be significantly higher in stage II-IIIa than stage I NSCLC. PMID: 24103781
  5. Sp17 is highly expressed in hepatocellular carcinoma cells PMID: 23923079
  6. SP17 was expressed in many cancer types with an overall frequency of 12%. SP17 was most frequently expressed in a different set of cancer types than MAGE-A and GAGE antigens and rarely overlapped with these proteins. PMID: 23137323
  7. Sperm protein 17 is highly expressed in endometrial and cervical cancers. PMID: 20712874
  8. Data show that cisplatin induced decrease in Sp17 levels was due to transcriptional inhibition and cisplatin-resistant cell lines did not show this decrease in Sp17 levels in response to cisplatin treatment. PMID: 19685492
  9. Sp17 has different expression patterns in cancer cell lines as compared to normal non-testes tissues and a potential pathogenic role in diseased cells PMID: 12213290
  10. focuses on the characterization of the genomic organization of an intron-containing gene and establishes a new transcription model PMID: 12393185
  11. expression of Sp17, a thought to be gamete-specific protein, in the synoviocytes of 8/8 female rheumatoid arthritis patients PMID: 12739786
  12. identification of a nonapeptide sequence within the Sp17 protein that is predicted to have a high binding affinity for HLA-A1 molecules PMID: 14566839
  13. Sp17 is expressed in the cell nucleus of ovarian neoplasms PMID: 14712480
  14. Sp17 gene expression in myeloma cells is regulated by promoter methylation PMID: 15381930
  15. Overexpression of sperm protein 17 is associated with esophageal cancer PMID: 17230514
  16. in vitro cultured, monoclonal, cytotoxic T lymphocytes (derived either from advanced OC patients or from healthy donors), specific for sperm protein 17, can eradicate human metastatic OC cells. PMID: 18779750
  17. Results suggest a possible role of Sp17 in regulating sperm maturation, capacitation, acrosomal reaction and interactions with the oocyte zona pellucida during the fertilization process. PMID: 19604394
  18. HSp17 plays a role in metastatic disease and resistance of epithelial ovarian carcinoma to chemotherapy PMID: 19744347

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Subcellular Location
Membrane; Peripheral membrane protein.
Tissue Specificity
Testis and sperm specific.
Database Links

HGNC: 11210

OMIM: 608621

KEGG: hsa:53340

STRING: 9606.ENSP00000227135

UniGene: Hs.286233

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