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SPON2 Antibody

Datasheet
Code CSB-PA006509
Size US$100
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  • Western Blotting(WB) 1- SPON2 Antibody
    Western Blot analysis of COS-7 cells using Mindin Polyclonal Antibody
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Product Details

Uniprot No.
Q9BUD6
Target Names
SPON2
Alternative Names
Differentially expressed in cancerous and non-cancerous lung cells 1 antibody; DIL 1 antibody; DIL-1 antibody; DIL1 antibody; DKFZp686G21139 antibody; FLJ16313 antibody; FLJ22401 antibody; FLJ34460 antibody; M spondin antibody; Mindin antibody; ORF Names: antibody; SPON 2 antibody; Spon2 antibody; SPON2_HUMAN antibody; Spondin 2 antibody; Spondin 2 extracellular matrix protein antibody; Spondin-2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human Mindin.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Protocols
Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

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Target Background

Function
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens. Binds bacterial lipopolysaccharide (LPS).
Gene References into Functions
  1. Egr-1 regulates mindin expression by directly binding to the mindin promoter; mindin suppresses colon cancer progression by blocking angiogenesis. PMID: 28991232
  2. Spondin-2 overexpression contributes to tumor aggressiveness and prognosis in gastric cancer. PMID: 28060752
  3. SPON2 is a transcriptional target of the metastasis gene MACC1. SPON2 induces cell motility in vitro and CRC metastasis in mice. In patients, SPON2 serves as prognostic indicator for CRC metastasis and survival, and might represent a promising target for therapeutic approaches. PMID: 26686083
  4. Data suggest that spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer. PMID: 25945835
  5. Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT-dependent manner. PMID: 25751394
  6. Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa patients with metastasis. PMID: 22615945
  7. mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT/GSK3beta and TGF-beta1-Smad signalling. PMID: 21632881
  8. High Mindin is associated with diabetic nephropathy in type 2 diabetes. PMID: 21098016
  9. Spondin 2, which is regulated by T(3), has an important role in cell invasion, cell migration, and hepatoma tumor progression. PMID: 19903741
  10. The structure of the F-spondin domain of mindin was determined at 1.8-A resolution. PMID: 19153605

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Subcellular Location
Secreted, extracellular space, extracellular matrix.
Tissue Specificity
Expressed in normal lung tissue but not in lung carcinoma cell lines.
Database Links

HGNC: 11253

OMIM: 605918

KEGG: hsa:10417

STRING: 9606.ENSP00000290902

UniGene: Hs.302963

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