SPPL2B Antibody

Datasheet
Code CSB-PA823457LA01HU
See More Details Free Antibody trial simple
Size US$299
Uniprot No. Q8TCT7
Image
  • Immunofluorescence staining of A549 cells with CSB-PA823457LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Protocols ELISA Protocol
Immunofluorescence (IF) Protocol
Immunogen Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IF; Recommended dilution: IF:1:50-1:200
Relevance Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1), SPPL2B, IMP4 KIAA1532 PSL1
Immunogen Species Human
Research Area Others
Target Names SPPL2B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing
Subcellular Location Cell membrane, Multi-pass membrane protein, Golgi apparatus membrane, Multi-pass membrane protein, Lysosome membrane, Multi-pass membrane protein, Endosome membrane, Multi-pass membrane protein, Membrane, Multi-pass membrane protein, Lumenal side
Protein Families Peptidase A22B family
Tissue Specificity Expressed predominantly in adrenal cortex and mammary gland.
Database Links

HGNC: 30627

OMIM: 608239

KEGG: hsa:56928

UniGene: Hs.744026

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