SRSF7 Antibody

Code CSB-PA244022
Size US$297
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  • Western blot analysis of extracts from HT-29 cells, using SFRS7 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SRSF7 Polyclonal antibody
Uniprot No.
Target Names
SRSF7
Alternative Names
9G8 antibody; AAG3 antibody; arginine/serine-rich 7 antibody; HSSG1 antibody; RBM37 antibody; Serine/arginine-rich splicing factor 7 antibody; Splicing factor 9G8 antibody; Splicing factor antibody; Splicing factor, arginine/serine rich 7 antibody; SRSF7 antibody; SRSF7_HUMAN antibody; ZCCHC20 antibody; ZCRB2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human SFRS7.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Gene References into Functions
  1. role of SRSF7 in cell proliferation through regulating p21 levels. PMID: 27644562
  2. SRSF7 expression in cancer cells is regulated by microRNAs: short, non-coding RNAs that bind to 3'UTR of target genes and downregulate their expression. SRSF7 regulate proliferation of renal cancer cells.SRSF7 regulates expression of osteopontin. PMID: 27664584
  3. Genome-wide identification of CD95 antigen alternative splicing regulators, such as SRSF7, reveals links with iron homeostasis. PMID: 25482508
  4. Coexpression of Dyrk1A and splicing factor 9G8 leads to their translocation from the nucleus to the cytoplasm and suppresses their ability to regulate tau exon 10 splicing. PMID: 21215488
  5. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10 PMID: 22677170
  6. Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration. PMID: 21755018
  7. These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases. PMID: 17137791
  8. 9G8 was shown to enhance expression of unspliced RNA containing either the Mason-Pfizer monkey virus constitutive transport element PMID: 17513303
  9. eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). PMID: 19854136

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Splicing factor SR family
Tissue Specificity
Brain, liver, kidney and lung.
Database Links

HGNC: 10789

OMIM: 600572

KEGG: hsa:6432

STRING: 9606.ENSP00000325905

UniGene: Hs.309090

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